Literature DB >> 15908418

A rot mutation restores parental virulence to an agr-null Staphylococcus aureus strain in a rabbit model of endocarditis.

Peter J McNamara1, Arnold S Bayer.   

Abstract

Mutations in rot restore in vitro toxin production to agr-negative strains of Staphylococcus aureus. We show that a rot mutation returns wild-type virulence to an agr mutant, as measured in experimental endocarditis infections by target organ bacterial counts. Implications of our data are discussed in terms of agr antagonist strategies.

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Year:  2005        PMID： 15908418      PMCID： PMC1111829          DOI： 10.1128/IAI.73.6.3806-3809.2005

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  28 in total

Review 1.  Pathogenesis of streptococcal and staphylococcal endocarditis.

Authors:  Philippe Moreillon; Yok A Que; Arnold S Bayer
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Review 2.  Autoinduction and signal transduction in the regulation of staphylococcal virulence.

Authors:  Richard P Novick
Journal:  Mol Microbiol       Date:  2003-06       Impact factor: 3.501

Review 3.  Have the oxazolidinones lived up to their billing? Future perspectives for this antibacterial class.

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Journal:  Curr Opin Investig Drugs       Date:  2003-02

4.  Multiple mechanisms for the activation of human platelet aggregation by Staphylococcus aureus: roles for the clumping factors ClfA and ClfB, the serine-aspartate repeat protein SdrE and protein A.

Authors:  Louise O'Brien; Steven W Kerrigan; Gideon Kaw; Michael Hogan; José Penadés; David Litt; Desmond J Fitzgerald; Timothy J Foster; Dermot Cox
Journal:  Mol Microbiol       Date:  2002-05       Impact factor: 3.501

5.  In vitro susceptibility to thrombin-induced platelet microbicidal protein is associated with reduced disease progression and complication rates in experimental Staphylococcus aureus endocarditis: microbiological, histopathologic, and echocardiographic analyses.

Authors:  Leon Iri Kupferwasser; Michael R Yeaman; Shelley M Shapiro; Cynthia C Nast; Arnold S Bayer
Journal:  Circulation       Date:  2002-02-12       Impact factor: 29.690

6.  Functional blocking of Staphylococcus aureus adhesins following growth in ex vivo media.

Authors:  Ruth C Massey; Shobana R Dissanayeke; Brian Cameron; David Ferguson; Timothy J Foster; Sharon J Peacock
Journal:  Infect Immun       Date:  2002-10       Impact factor: 3.441

Review 7.  Global regulation of virulence determinants in Staphylococcus aureus by the SarA protein family.

Authors:  Ambrose L Cheung; Gongyi Zhang
Journal:  Front Biosci       Date:  2002-08-01

8.  Global regulation of Staphylococcus aureus genes by Rot.

Authors:  B Saïd-Salim; P M Dunman; F M McAleese; D Macapagal; E Murphy; P J McNamara; S Arvidson; T J Foster; S J Projan; B N Kreiswirth
Journal:  J Bacteriol       Date:  2003-01       Impact factor: 3.490

9.  Characterization of RAP, a quorum sensing activator of Staphylococcus aureus.

Authors:  Moshe Korem; Abhineet S Sheoran; Yael Gov; Saul Tzipori; Ilya Borovok; Naomi Balaban
Journal:  FEMS Microbiol Lett       Date:  2003-06-27       Impact factor: 2.742

10.  An engineered multidomain bactericidal peptide as a model for targeted antibiotics against specific bacteria.

Authors:  Xiao-Qing Qiu; He Wang; Xiao-Fong Lu; Jie Zhang; Sheng-Fu Li; Gang Cheng; Lin Wan; Li Yang; Jun-Yong Zuo; Yu-Qi Zhou; Hai-Yun Wang; Xin Cheng; Su-Hua Zhang; Zheng-Rong Ou; Zi-Cheng Zhong; Jing-Qiu Cheng; You-Ping Li; George Y Wu
Journal:  Nat Biotechnol       Date:  2003-11-16       Impact factor: 54.908
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  15 in total

1.  Staphylococcus aureus leucocidin ED contributes to systemic infection by targeting neutrophils and promoting bacterial growth in vivo.

Authors:  Francis Alonzo; Meredith A Benson; John Chen; Richard P Novick; Bo Shopsin; Victor J Torres
Journal:  Mol Microbiol       Date:  2011-12-20       Impact factor: 3.501

Review 2.  Peptide signaling in the staphylococci.

Authors:  Matthew Thoendel; Jeffrey S Kavanaugh; Caralyn E Flack; Alexander R Horswill
Journal:  Chem Rev       Date:  2010-12-21       Impact factor: 60.622

3.  SarA is a repressor of hla (alpha-hemolysin) transcription in Staphylococcus aureus: its apparent role as an activator of hla in the prototype strain NCTC 8325 depends on reduced expression of sarS.

Authors:  Jan Oscarsson; Anna Kanth; Karin Tegmark-Wisell; Staffan Arvidson
Journal:  J Bacteriol       Date:  2006-09-29       Impact factor: 3.490

4.  Staphylococcal superantigen-like genes, ssl5 and ssl8, are positively regulated by Sae and negatively by Agr in the Newman strain.

Authors:  Madhulatha Pantrangi; Vineet K Singh; Christiane Wolz; Sanjay K Shukla
Journal:  FEMS Microbiol Lett       Date:  2010-05-14       Impact factor: 2.742

Review 5.  The bicomponent pore-forming leucocidins of Staphylococcus aureus.

Authors:  Francis Alonzo; Victor J Torres
Journal:  Microbiol Mol Biol Rev       Date:  2014-06       Impact factor: 11.056

6.  Rot and Agr system modulate fibrinogen-binding ability mainly by regulating clfB expression in Staphylococcus aureus NCTC8325.

Authors:  Ting Xue; Yibo You; Fei Shang; Baolin Sun
Journal:  Med Microbiol Immunol       Date:  2011-06-24       Impact factor: 3.402

7.  Staphylococcus aureus regulates the expression and production of the staphylococcal superantigen-like secreted proteins in a Rot-dependent manner.

Authors:  Meredith A Benson; Sarit Lilo; Gregory A Wasserman; Matthew Thoendel; Amanda Smith; Alexander R Horswill; John Fraser; Richard P Novick; Bo Shopsin; Victor J Torres
Journal:  Mol Microbiol       Date:  2011-06-16       Impact factor: 3.501

8.  Regulation of hemolysin expression and virulence of Staphylococcus aureus by a serine/threonine kinase and phosphatase.

Authors:  Kellie Burnside; Annalisa Lembo; Melissa de Los Reyes; Anton Iliuk; Nguyen-Thao Binhtran; James E Connelly; Wan-Jung Lin; Byron Z Schmidt; Anthony R Richardson; Ferric C Fang; Weiguo Andy Tao; Lakshmi Rajagopal
Journal:  PLoS One       Date:  2010-06-11       Impact factor: 3.240

9.  Evolution of hypervirulence by a MRSA clone through acquisition of a transposable element.

Authors:  Meredith A Benson; Elizabeth A Ohneck; Chanelle Ryan; Francis Alonzo; Hannah Smith; Apurva Narechania; Sergios-Orestis Kolokotronis; Sarah W Satola; Anne-Catrin Uhlemann; Robert Sebra; Gintaras Deikus; Bo Shopsin; Paul J Planet; Victor J Torres
Journal:  Mol Microbiol       Date:  2014-07-16       Impact factor: 3.501

10.  Expression of the sarA family of genes in different strains of Staphylococcus aureus.

Authors:  Anand Ballal; Adhar C Manna
Journal:  Microbiology (Reading)       Date:  2009-04-23       Impact factor: 2.777
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