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Literature DB >> 15908404

Deletion of the ferric uptake regulator Fur impairs the in vitro growth and virulence of Actinobacillus pleuropneumoniae.

Ilse Jacobsen¹, Jörg Gerstenberger, Achim D Gruber, Janine T Bossé, Paul R Langford, Isabel Hennig-Pauka, Jochen Meens, Gerald-F Gerlach.

Abstract

In order to investigate the role of the ferric uptake regulator Fur in the porcine lung pathogen Actinobacillus pleuropneumoniae, we constructed an isogenic in-frame deletion mutant, A. pleuropneumoniae Deltafur. This mutant showed constitutive expression of transferrin-binding proteins, growth deficiencies in vitro, and reduced virulence in an aerosol infection model.

Entities: Chemical

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Year: 2005 PMID： 15908404 PMCID： PMC1111875 DOI： 10.1128/IAI.73.6.3740-3744.2005

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

29 in total

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