Literature DB >> 15908033

Influence of the drug compatibility with polymer solution on the release kinetics of electrospun fiber formulation.

Jing Zeng1, Lixin Yang, Qizhi Liang, Xuefei Zhang, Huili Guan, Xiuling Xu, Xuesi Chen, Xiabin Jing.   

Abstract

The electrospun fiber mat for drug delivery is a novel formulation with promising clinical applications in the future. The influence of the solubility and compatibility of drugs in the drug/polymer/solvent system on the encapsulation of the drug inside the poly(L-lactide) (PLLA) electrospun fibers and the release behavior of this formulation were examined by using paclitaxel, doxorubicin hydrochloride and doxorubicin base as model drugs. The burst release of the drugs can be avoided by using compatible drugs with polymers, and the drug release can follow nearly zero-order kinetics due to the degradation of the PLLA fibers in the presence of proteinase K.

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Year:  2005        PMID： 15908033     DOI： 10.1016/j.jconrel.2005.02.024

Source DB:  PubMed          Journal:  J Control Release        ISSN： 0168-3659            Impact factor:   9.776


  48 in total

1.  Fabrication and evaluation of electrospun collagen/poly(N-isopropyl acrylamide)/chitosan mat as blood-contacting biomaterials for drug delivery.

Authors:  Saravanabhavan Shanmuga Sundar; Dharmalingam Sangeetha
Journal:  J Mater Sci Mater Med       Date:  2012-04-03       Impact factor: 3.896

2.  3D superhydrophobic electrospun meshes as reinforcement materials for sustained local drug delivery against colorectal cancer cells.

Authors:  Stefan T Yohe; Victoria L M Herrera; Yolonda L Colson; Mark W Grinstaff
Journal:  J Control Release       Date:  2012-06-06       Impact factor: 9.776

3.  Controlled delivery of fibroblast growth factor-9 from biodegradable poly(ester amide) fibers for building functional neovasculature.

Authors:  Somiraa S Said; J Geoffrey Pickering; Kibret Mequanint
Journal:  Pharm Res       Date:  2014-05-24       Impact factor: 4.200

4.  Electrospinning jets and nanofibrous structures.

Authors:  Koyal Garg; Gary L Bowlin
Journal:  Biomicrofluidics       Date:  2011-03-30       Impact factor: 2.800

5.  Removal of Retained Electrospinning Solvent Prolongs Drug Release from Electrospun PLLA Fibers.

Authors:  Anthony R D'Amato; Nicholas J Schaub; Jesus M Cardenas; Andrew S Fiumara; Paul M Troiano; Andrea Fischetti; Ryan J Gilbert
Journal:  Polymer (Guildf)       Date:  2017-07-03       Impact factor: 4.430

Review 6.  Emerging Roles of Electrospun Nanofibers in Cancer Research.

Authors:  Shixuan Chen; Sunil Kumar Boda; Surinder K Batra; Xiaoran Li; Jingwei Xie
Journal:  Adv Healthc Mater       Date:  2017-12-06       Impact factor: 9.933

7.  Compatible stability of methylprednisolone sodium succinate and tropisetron in 0.9% sodium chloride injection.

Authors:  Chen Peng; Jie-Xin Lei
Journal:  Eur J Hosp Pharm       Date:  2018-12-01

8.  Tunable Release of Multiclass Anti-HIV Drugs that are Water-Soluble and Loaded at High Drug Content in Polyester Blended Electrospun Fibers.

Authors:  Daniel Carson; Yonghou Jiang; Kim A Woodrow
Journal:  Pharm Res       Date:  2015-08-19       Impact factor: 4.200

9.  Doxycycline poly e-caprolactone nanofibers in patients with chronic periodontitis - a clinical evaluation.

Authors:  T P Chaturvedi; Ruchi Srivastava; A K Srivastava; Varun Gupta; Pushpendra Kumar Verma
Journal:  J Clin Diagn Res       Date:  2013-10-05

Review 10.  Biomimetic and bioactive nanofibrous scaffolds from electrospun composite nanofibers.

Authors:  Y Z Zhang; B Su; J Venugopal; S Ramakrishna; C T Lim
Journal:  Int J Nanomedicine       Date:  2007
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