| Literature DB >> 15907478 |
Elisabetta Straface1, Paola Matarrese, Lucrezia Gambardella, Rosa Vona, Antonio Sgadari, Maria Caterina Silveri, Walter Malorni.
Abstract
Markers of oxidative stress in peripheral blood from patients with Alzheimer disease (AD) were analyzed. Thirty-three AD patients were recruited. Plasma antioxidant power (AOP), plasma Cystatin C as well as Cathepsin D in PBL were evaluated. We found that the AOP levels were significantly decreased in AD patients if compared to healthy donors, while the plasma level of Cystatin C was significantly higher. Importantly, a significantly decreased expression of Cathepsin D in PBL was also observed. These results suggest that oxidative imbalance in the peripheral blood of AD patients could mirror oxidative changes previously described in the central nervous system.Entities:
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Year: 2005 PMID： 15907478 DOI： 10.1016/j.febslet.2005.03.094
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124