| Literature DB >> 15907367 |
Maria Teresa Bortolin1, Chiara Pratesi, Riccardo Dolcetti, Ettore Bidoli, Emanuela Vaccher, Stefania Zanussi, Rosamaria Tedeschi, Paolo De Paoli.
Abstract
We investigated EBV viremia in matched serum and peripheral blood mononuclear cells (PBMCs) from one of the largest Italian cohort of Undifferentiated Carcinoma of Nasopharyngeal Type (UCNT) patients (N=34). By using a LMP-1 real-time PCR assay, we found that EBV DNA detection rate was 74% (median 8417 copies/ml) and 24% (median 164 copies/10(6)cells) on serum and PBMCs, respectively. Significantly higher serum EBV DNA levels were detected in patients with advanced UCNT (nodal stage N2 versus N0-1 and N3 versus N0-1, P=0.03 and 0.018; overall stage IV versus I-II, P=0.03). During the follow-up, there was also a statistically significant difference of EBV DNA viral load between patients with and without clinical relapse (P=0.008). We concluded that serum EBV DNA reflects the biological activity of the UCNT and may be a prognostic factor also in a low-incidence region.Entities:
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Year: 2006 PMID： 15907367 DOI： 10.1016/j.canlet.2005.03.015
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679