Literature DB >> 15907348

Chemotherapy of leishmaniasis part II: synthesis and bioevaluation of substituted arylketene dithioacetals as antileishmanial agents.

Susmita Pandey1, S N Suryawanshi, Suman Gupta, V M L Srivastava.   

Abstract

Some novel aryl substituted ketene dithioacetals have been synthesized using novel synthetic methods. The compounds were screened against Leishmania donovani in hamsters for their activity profile. Some of the compounds inhibited 50-65% parasite growth at 50 mg kg(-1) x 5 days.

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Year:  2005        PMID: 15907348     DOI: 10.1016/j.ejmech.2005.02.007

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN: 0223-5234            Impact factor:   6.514


  6 in total

1.  Amiodarone triggers induction of apoptosis in cutaneous leishmaniasis agents.

Authors:  Somayeh Bahrami; Shahram Khademvatan; Mohammad Hossein Razi Jalali; Sepide Pourbaram
Journal:  Pathog Glob Health       Date:  2016-08-24       Impact factor: 2.894

2.  1-(2-Naphth-yl)-3-phenyl-prop-2-en-1-one.

Authors:  Si-Ping Tang; Dai-Zhi Kuang; Yong-Lan Feng; Man-Sheng Chen; Wei Li
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-07-04

3.  (E)-3-(3-Bromo-phen-yl)-1-(4-methyl-phenyl)prop-2-en-1-one.

Authors:  Hongqi Li; B K Sarojini; C G D Raj; L N Madhu; H S Yathirajan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-10-31

4.  Amiodarone destabilizes intracellular Ca2+ homeostasis and biosynthesis of sterols in Leishmania mexicana.

Authors:  Xenón Serrano-Martín; Yael García-Marchan; Alexis Fernandez; Noris Rodriguez; Hector Rojas; Gonzalo Visbal; Gustavo Benaim
Journal:  Antimicrob Agents Chemother       Date:  2009-01-21       Impact factor: 5.191

5.  (E)-1-[4-(Prop-2-yn-1-yl-oxy)phen-yl]-3-(3,4,5-trimeth-oxy-phen-yl)prop-2-en-1-one.

Authors:  S Ranjith; A Thirunarayanan; S Raja; P Rajakumar; A Subbiahpandi
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-08-11

6.  Facile synthesis of novel dithioacetal-naphthalene derivatives as potential activators for plant resistance induction.

Authors:  R J Ji; W M Shi; D Y Tian; G P Zhang; H Wang
Journal:  RSC Adv       Date:  2019-10-10       Impact factor: 4.036

  6 in total

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