Literature DB >> 15905855

Immunotherapy for pancreatic cancer - science driving clinical progress.

Dan Laheru1, Elizabeth M Jaffee.   

Abstract

The identification of key signalling pathways involved in immune-system regulation, along with the development of early pancreatic tumours in mouse models have provided new opportunities for pancreatic cancer treatment and prevention. Immunotherapy for pancreatic cancer is one approach that is at a crucial crossroads, as therapeutics that are designed to target pancreatic-cancer-associated antigens and regulatory signalling molecules are entering clinical trials.

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Year:  2005        PMID: 15905855     DOI: 10.1038/nrc1630

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN: 1474-175X            Impact factor:   60.716


  77 in total

1.  Mutant KRAS-induced expression of ICAM-1 in pancreatic acinar cells causes attraction of macrophages to expedite the formation of precancerous lesions.

Authors:  Geou-Yarh Liou; Heike Döppler; Brian Necela; Brandy Edenfield; Lizhi Zhang; David W Dawson; Peter Storz
Journal:  Cancer Discov       Date:  2014-10-31       Impact factor: 39.397

2.  Immune response after photodynamic therapy increases anti-cancer and anti-bacterial effects.

Authors:  Eleonora Reginato; Peter Wolf; Michael R Hamblin
Journal:  World J Immunol       Date:  2014-03-27

3.  Downstream mediators of the intratumoral interferon response suppress antitumor immunity, induce gemcitabine resistance and associate with poor survival in human pancreatic cancer.

Authors:  Daniel Delitto; Chelsey Perez; Song Han; David H Gonzalo; Kien Pham; Andrea E Knowlton; Christina L Graves; Kevin E Behrns; Lyle L Moldawer; Ryan M Thomas; Chen Liu; Thomas J George; Jose G Trevino; Shannon M Wallet; Steven J Hughes
Journal:  Cancer Immunol Immunother       Date:  2015-09-30       Impact factor: 6.968

Review 4.  Current progress in immunotherapy for pancreatic cancer.

Authors:  Kelly Foley; Victoria Kim; Elizabeth Jaffee; Lei Zheng
Journal:  Cancer Lett       Date:  2015-12-23       Impact factor: 8.679

5.  Cancer gene therapy: combination with radiation therapy and the role of bystander cell killing in the anti-tumor effect.

Authors:  Katalin Lumniczky; Géza Sáfrány
Journal:  Pathol Oncol Res       Date:  2006-06-24       Impact factor: 3.201

6.  Mechanism and therapeutic reversal of immune suppression in cancer.

Authors:  Donna L Herber; Srinivas Nagaraj; Julie Y Djeu; Dmitry I Gabrilovich
Journal:  Cancer Res       Date:  2007-06-01       Impact factor: 12.701

Review 7.  Biology and management of pancreatic cancer.

Authors:  Paula Ghaneh; Eithne Costello; John P Neoptolemos
Journal:  Gut       Date:  2007-08       Impact factor: 23.059

8.  Midkine promotes perineural invasion in human pancreatic cancer.

Authors:  Jun Yao; Wen-Yao Li; Shuo-Guo Li; Xiao-Shan Feng; She-Gan Gao
Journal:  World J Gastroenterol       Date:  2014-03-21       Impact factor: 5.742

9.  Immunotherapy updates in pancreatic cancer: are we there yet?

Authors:  Krishna Soujanya Gunturu; Gabriela R Rossi; Muhammad Wasif Saif
Journal:  Ther Adv Med Oncol       Date:  2013-01       Impact factor: 8.168

10.  Potential plasticity of T regulatory cells in pancreatic carcinoma in relation to disease progression and outcome.

Authors:  Barbara Vizio; Anna Novarino; Alice Giacobino; Carmen Cristiano; Adriana Prati; Libero Ciuffreda; Giuseppe Montrucchio; Graziella Bellone
Journal:  Exp Ther Med       Date:  2012-04-18       Impact factor: 2.447

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