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Literature DB >> 159020

D-penicillamine and immune complex deposition.

J D Kirby, P A Dieppe, E C Huskisson, B Smith.

Abstract

Dense, granular immunoglobulin deposits have been identified at the epidermo-dermal junction in 4 out of 10 patients who developed toxic reactions to D-penicillamine therapy for rheumatoid arthritis. Three of 4 patients developing a lupus-like syndrome while on penicillamine had similar findings on skin biopsy. Serum immunoglobulin and complement levels decreased significantly in patients treated with penicillamine. It is suggested that, in addition to penicillamine nephropathy, other side effects of this drug may be related to widespread deposition of immune complexes.

Entities: Chemical Disease Species

Mesh：

Substances：
Penicillamine

Year: 1979 PMID： 159020 PMCID： PMC1000368 DOI： 10.1136/ard.38.4.344

Source DB: PubMed Journal: Ann Rheum Dis ISSN： 0003-4967 Impact factor: 19.103

10 in total

1. Specific therapy for rheumatoid arthritis.

Authors: E C Huskisson
Journal: Rheumatol Rehabil Date: 1976-08

2. [100 cases of common rheumatoid polyarthritis, treated with D-penicillamin].

Authors: J P Camus; J Crouzet; P Guillien; C Benichou; J A Lievre
Journal: Ann Med Interne (Paris) Date: 1974-01

Review 3. The diagnosis of systemic lupus erythematosus.

Authors: G R Hughes
Journal: Br J Haematol Date: 1973-10 Impact factor: 6.998

4. Detection and radioassay of soluble circulating immune complexes using guinea pig peritoneal exudate cells.

Authors: I I Onyewotu; E J Holborow; G D Johnson
Journal: Nature Date: 1974-03-08 Impact factor: 49.962

5. Lupus-like syndrome induced by D-penicillamine in Wilson's disease.

Authors: J P Harpey; B Caille; R Moulias; J M Goust
Journal: Lancet Date: 1971-02-06 Impact factor: 79.321

6. Nephropathy induced by D-penicillamine.

Authors: I A Jaffe; G Treser; Y Suzuki; T Ehrenreich
Journal: Ann Intern Med Date: 1968-09 Impact factor: 25.391

7. Effect of D-penicillamine on serum immunoglobulins and rheumatoid factor.

Authors: R Bluestone; L S Goldberg
Journal: Ann Rheum Dis Date: 1973-01 Impact factor: 19.103

8. Effect of penicillamine therapy on circulating immune complexes in rheumatoid arthritis.

Authors: I Mohammed; D Barraclough; E J Holborow; B M Ansell
Journal: Ann Rheum Dis Date: 1975-10 Impact factor: 19.103

9. Penicillamine nephropathy in rheumatoid arthritis. A clinical, pathological and immunological study.

Authors: P A Bacon; C R Tribe; J C Mackenzie; J Verrier-Jones; R H Cumming; B Amer
Journal: Q J Med Date: 1976-10

10. Factors relating to circulating immune complexes in rheumatoid arthirits.

Authors: P J Roberts-Thomson; B L Hazleman; I G Barnett; I C MacLennan; A G Mowat
Journal: Ann Rheum Dis Date: 1976-08 Impact factor: 19.103

10 in total

7 in total

1. Immune deposits at the dermoepidermal junction in patients with rheumatoid arthritis.

Authors: P A Brougham; P E McGill; J Tulloch
Journal: Ann Rheum Dis Date: 1984-06 Impact factor: 19.103

2. [Goodpasture's syndrome--rapid remission after early plasmapheresis and high-dose cyclophosphamide therapy (author's transl)].

Authors: H H Euler; L Kleine; H J Gutschmidt; J D Herrlinger
Journal: Klin Wochenschr Date: 1982-06-15