Literature DB >> 15901173

Synthesis of nucleoside alpha-thiotriphosphates via an oxathiaphospholane approach.

Konrad Misiura1, Daria Szymanowicz, Wojciech J Stec.   

Abstract

[reaction: see text]. Nucleoside 5'-O-(alpha-thiotriphosphates) were obtained in reactions of the appropriate nucleoside 5'-O-(2-thio-1,3,2-oxathiaphospholanes) with pyrophosphate in the presence of DBU. The presented method allows also for preparation of alpha-seleno congeners and corresponding alpha-modified diphosphates.

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Year:  2005        PMID： 15901173     DOI： 10.1021/ol050617r

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  4 in total

1.  2-MeS-beta,gamma-CCl2-ATP is a potent agent for reducing intraocular pressure.

Authors:  Shay Eliahu; Alba Martín-Gil; María Jesús Perez de Lara; Jesús Pintor; Jean Camden; Gary A Weisman; Joanna Lecka; Jean Sévigny; Bilha Fischer
Journal:  J Med Chem       Date:  2010-04-22       Impact factor: 7.446

2.  Towards mRNA with superior translational activity: synthesis and properties of ARCA tetraphosphates with single phosphorothioate modifications.

Authors:  Malwina Strenkowska; Joanna Kowalska; Maciej Lukaszewicz; Joanna Zuberek; Wei Su; Robert E Rhoads; Edward Darzynkiewicz; Jacek Jemielity
Journal:  New J Chem       Date:  2010-01-01       Impact factor: 3.591

3.  Identification of hydrolytically stable and selective P2Y(1) receptor agonists.

Authors:  Shay E Eliahu; Jean Camden; Joanna Lecka; Gary A Weisman; Jean Sévigny; Sylvie Gélinas; Bilha Fischer
Journal:  Eur J Med Chem       Date:  2008-07-22       Impact factor: 6.514

4.  Cap analogs modified with 1,2-dithiodiphosphate moiety protect mRNA from decapping and enhance its translational potential.

Authors:  Malwina Strenkowska; Renata Grzela; Maciej Majewski; Katarzyna Wnek; Joanna Kowalska; Maciej Lukaszewicz; Joanna Zuberek; Edward Darzynkiewicz; Andreas N Kuhn; Ugur Sahin; Jacek Jemielity
Journal:  Nucleic Acids Res       Date:  2016-10-07       Impact factor: 16.971
  4 in total

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