Literature DB >> 15900333

A novel one-pot three-component synthesis of 3-halofurans and sequential Suzuki coupling.

Alexei S Karpov1, Eugen Merkul, Thomas Oeser, Thomas J J Müller.   

Abstract

A novel sequence of Sonogashira coupling and electrophilic addition to an ynone, with concomitant deprotection and cyclocondensation, opens a new one-pot synthesis of 3-halofurans; the method can be readily elaborated to a new sequential Sonogashira-addition-cyclocondensation-Suzuki reaction to furnish 2,3,5-trisubstituted furans in a one-pot fashion.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 15900333     DOI： 10.1039/b502324f

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  2 in total

Review 1.  Transition metal-mediated synthesis of monocyclic aromatic heterocycles.

Authors:  Anton V Gulevich; Alexander S Dudnik; Natalia Chernyak; Vladimir Gevorgyan
Journal:  Chem Rev       Date:  2013-01-10       Impact factor: 60.622

2.  Rapid pseudo five-component synthesis of intensively blue luminescent 2,5-di(hetero)arylfurans via a Sonogashira-Glaser cyclization sequence.

Authors:  Fabian Klukas; Alexander Grunwald; Franziska Menschel; Thomas J J Müller
Journal:  Beilstein J Org Chem       Date:  2014-03-18       Impact factor: 2.883
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.