CONTEXT: Low birth weight (LBW) is associated with increased risk of type 2 diabetes mellitus. An impaired incretin effect was reported previously in type 2 diabetic patients. OBJECTIVE: We studied the secretion and action of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) in young LBW men (n = 24) and matched normal birth weight controls (NBW) (n = 25). RESULTS: LBW subjects were 5 cm shorter but had a body mass index similar to NBW. LBW subjects had significantly elevated fasting and postprandial plasma glucose, as well as postprandial (standard meal test) plasma insulin and C-peptide concentrations, suggestive of insulin resistance. Insulin secretion in response to changes in glucose concentration ("beta-cell responsiveness") during the meal test was similar in LBW and NBW but inappropriate in LBW relative to insulin sensitivity. Fasting and postprandial plasma GLP-1 and GIP levels were similar in the groups. First- and second-phase insulin responses were similar in LBW and NBW during a hyperglycemic clamp (7 mm) with infusion of GLP-1 or GIP, respectively, demonstrating normal action of these hormones on insulin secretion. CONCLUSION: Reduced secretion or action of GLP-1 or GIP does not explain a relative reduced beta-cell responsiveness to glucose or the slightly elevated plasma glucose concentrations observed in young LBW men.
CONTEXT: Low birth weight (LBW) is associated with increased risk of type 2 diabetes mellitus. An impaired incretin effect was reported previously in type 2 diabeticpatients. OBJECTIVE: We studied the secretion and action of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) in young LBW men (n = 24) and matched normal birth weight controls (NBW) (n = 25). RESULTS: LBW subjects were 5 cm shorter but had a body mass index similar to NBW. LBW subjects had significantly elevated fasting and postprandial plasma glucose, as well as postprandial (standard meal test) plasma insulin and C-peptide concentrations, suggestive of insulin resistance. Insulin secretion in response to changes in glucose concentration ("beta-cell responsiveness") during the meal test was similar in LBW and NBW but inappropriate in LBW relative to insulin sensitivity. Fasting and postprandial plasma GLP-1 and GIP levels were similar in the groups. First- and second-phase insulin responses were similar in LBW and NBW during a hyperglycemic clamp (7 mm) with infusion of GLP-1 or GIP, respectively, demonstrating normal action of these hormones on insulin secretion. CONCLUSION: Reduced secretion or action of GLP-1 or GIP does not explain a relative reduced beta-cell responsiveness to glucose or the slightly elevated plasma glucose concentrations observed in young LBW men.
Authors: S E Ozanne; C B Jensen; K J Tingey; M S Martin-Gronert; L Grunnet; C Brons; H Storgaard; A A Vaag Journal: Diabetologia Date: 2006-10-25 Impact factor: 10.122
Authors: K Pilgaard; C B Jensen; J H Schou; V Lyssenko; L Wegner; C Brøns; T Vilsbøll; T Hansen; S Madsbad; J J Holst; A Vølund; P Poulsen; L Groop; O Pedersen; A A Vaag Journal: Diabetologia Date: 2009-03-14 Impact factor: 10.122
Authors: Valeriya Lyssenko; Lena Eliasson; Olga Kotova; Kasper Pilgaard; Nils Wierup; Albert Salehi; Anna Wendt; Anna Jonsson; Yang Z De Marinis; Lisa M Berglund; Jalal Taneera; Alexander Balhuizen; Ola Hansson; Peter Osmark; Pontus Dunér; Charlotte Brøns; Alena Stancáková; Johanna Kuusisto; Marco Bugliani; Richa Saxena; Emma Ahlqvist; Timothy J Kieffer; Tiinamaija Tuomi; Bo Isomaa; Olle Melander; Emily Sonestedt; Marju Orho-Melander; Peter Nilsson; Sara Bonetti; Riccardo Bonadonna; Roberto Miccoli; Stefano Delprato; Piero Marchetti; Sten Madsbad; Pernille Poulsen; Allan Vaag; Markku Laakso; Maria F Gomez; Leif Groop Journal: Diabetes Date: 2011-08-01 Impact factor: 9.461
Authors: L G Grunnet; K Pilgaard; A Alibegovic; C B Jensen; L Hjort; S E Ozanne; M Bennett; A Vaag; C Brøns Journal: Sci Rep Date: 2019-05-21 Impact factor: 4.379