| Literature DB >> 15899384 |
Geok Yee Lee1, Sivaswaren Christina, Sim Leng Tien, Anisah Bte Abdul Ghafar, William Hwang, Lay Cheng Lim, Tse Hui Lim.
Abstract
We describe a patient with acute promyelocytic leukemia (APL) and the karyotype 46,XX,i(17)(q10) with PML-RARA fusion gene detected by fluorescence in situ hybridization (FISH) and nested reverse transcriptase-polymerase chain reaction (RT-PCR). FISH using dual-color translocation probes for PML (promyelocytic leukemia) and RARA (retinoic acid receptor-alpha) showed fusion signal for PML-RARA on both arms of i(17q). The patient attained complete remission (CR) with all-trans retinoic acid treatment and became PML-RARA negative. One year later, while PML-RARA negative on FISH and RT-PCR, the patient presented with thrombocytopenia. Bone marrow examination suggested an acute monoblastic leukemia (AML-M5a) including the karyotype 46,XX,t(8;16) (p11.2;p13.3),inv(11)(p15q22 approximately q23)[11]/47,idem,+i(8)(q10)[9]. She is currently in CR. The occurrence of therapy related acute leukemia after successful therapy for APL is an emerging problem.Entities:
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Year: 2005 PMID： 15899384 DOI： 10.1016/j.cancergencyto.2004.09.019
Source DB: PubMed Journal: Cancer Genet Cytogenet ISSN： 0165-4608