INTRODUCTION: Melanoma is one of the neoplasias that most frequently metastasize, especially in the lung, where represents a challenge in oncology since current treatment is ineffective, and mortality is high. MATERIAL AND METHODS: Swiss mice (n = 52) were inoculated with 0.5 x 106 B16F10 cell lines and, later, given an oral administration of grape-seed extract, red wine or ethanol. Metastatic nodules on the lung surface were counted and, after processing for microscopy, five sections were selected for image analysis and the invasion index was calculated. RESULTS: Macroscopic analysis showed that grape-seed extract and red wine reduced the number of metastatic nodules by 26.07 and 20.81%, respectively, compared with a control group treated with ethanol. Microscopically, the reduction in the invasion index was 31.65 for grape-seed extract and 17.57% for red wine. CONCLUSION: Ethanol administration significantly increased pulmonary metastasis while grape-seed extract and red wine led to their reduction.
INTRODUCTION:Melanoma is one of the neoplasias that most frequently metastasize, especially in the lung, where represents a challenge in oncology since current treatment is ineffective, and mortality is high. MATERIAL AND METHODS: Swiss mice (n = 52) were inoculated with 0.5 x 106 B16F10 cell lines and, later, given an oral administration of grape-seed extract, red wine or ethanol. Metastatic nodules on the lung surface were counted and, after processing for microscopy, five sections were selected for image analysis and the invasion index was calculated. RESULTS: Macroscopic analysis showed that grape-seed extract and red wine reduced the number of metastatic nodules by 26.07 and 20.81%, respectively, compared with a control group treated with ethanol. Microscopically, the reduction in the invasion index was 31.65 for grape-seed extract and 17.57% for red wine. CONCLUSION:Ethanol administration significantly increased pulmonary metastasis while grape-seed extract and red wine led to their reduction.
Authors: E M Tabengwa; H E Grenett; R L Benza; L H Abou-Agag; J K Tresnak; C G Wheeler; F M Booyse Journal: Alcohol Clin Exp Res Date: 2001-02 Impact factor: 3.455
Authors: S Caltagirone; C Rossi; A Poggi; F O Ranelletti; P G Natali; M Brunetti; F B Aiello; M Piantelli Journal: Int J Cancer Date: 2000-08-15 Impact factor: 7.396
Authors: Elizabeth T Eng; JingJing Ye; Dudley Williams; Sheryl Phung; Roger E Moore; Mary K Young; Ugis Gruntmanis; Glenn Braunstein; Shiuan Chen Journal: Cancer Res Date: 2003-12-01 Impact factor: 12.701