| Literature DB >> 15897982 |
Christopher S Carlson1, Shelley Force Aldred, Philip K Lee, Russell P Tracy, Stephen M Schwartz, Mark Rieder, Kiang Liu, O Dale Williams, Carlos Iribarren, E Cora Lewis, Myriam Fornage, Eric Boerwinkle, Myron Gross, Cashell Jaquish, Deborah A Nickerson, Richard M Myers, David S Siscovick, Alexander P Reiner.
Abstract
Elevated plasma levels of C-reactive protein (CRP), an inflammation-sensitive marker, have emerged as an important predictor of future cardiovascular disease and metabolic abnormalities in apparently healthy men and women. Here, we performed a systematic survey of common nucleotide variation across the genomic region encompassing the CRP gene locus. Of the common single-nucleotide polymorphisms (SNPs) identified, several in the CRP promoter region are strongly associated with CRP levels in a large cohort study of cardiovascular risk in European American and African American young adults. We also demonstrate the functional importance of these SNPs in vitro.Entities:
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Year: 2005 PMID： 15897982 PMCID： PMC1226195 DOI： 10.1086/431366
Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025