Literature DB >> 15897638

Alpha-fetoprotein (AFP)- and des-gamma-carboxy prothrombin (DCP)-producing adenocarcinoma of the stomach with liver metastasis in a patient with chronic hepatitis C.

Tetsuro Sohda1, Yoshitaka Tomioka, Shinjiro Inomata, Isamu Morita, Koichi Eguchi, Kunihiko Aoyagi, Hiroshi Watanabe, Shotaro Nakamura, Shotaro Sakisaka.   

Abstract

A 45-year-old man was admitted to our hospital because of chronic hepatitis C and a large liver tumor accompanied by increased serum levels of alpha-fetoprotein (AFP) and des-gamma-carboxy prothrombin (DCP), the tumor markers for hepatocellular carcinoma. Endoscopic examination revealed advanced gastric cancer. Biopsy specimens of the stomach and liver showed gastric adenocarcinoma and its metastasis to the liver. Immunohistochemical studies demonstrated that adenocarcinoma cells both of the stomach and liver, were positive for the antibodies against AFP as well as DCP. Expression of AFP mRNA was shown in the cancer cells of the stomach. Accordingly, we diagnosed this patient with AFP- and DCP-producing adenocarcinoma of the stomach together with liver metastasis.

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Year:  2005        PMID： 15897638     DOI： 10.2169/internalmedicine.44.294

Source DB:  PubMed          Journal:  Intern Med        ISSN： 0918-2918            Impact factor:   1.271


  4 in total

1.  Protein induced by vitamin K absence or antagonist II-producing gastric cancer.

Authors:  Yoshihisa Takahashi; Tohru Inoue; Toshio Fukusato
Journal:  World J Gastrointest Pathophysiol       Date:  2010-10-15

2.  Elevated paraneoplastic hypercholesterolemia in a case of hepatoid adenocarcinoma of the stomach with liver metastasis.

Authors:  Tetsuro Sohda; Hiroyuki Kusuhara; Yoshiki Egashira; Keisuke Egashira; Koichi Eguchi; Kunihiko Aoyagi; Shotaro Sakisaka
Journal:  Clin J Gastroenterol       Date:  2013-09-14

3.  Hepatoid carcinoma of the pancreas producing protein induced by vitamin K absence or antagonist II (PIVKA-II) and alpha-fetoprotein (AFP).

Authors:  Kazuhiro Matsueda; Hiroshi Yamamoto; Yasuo Yoshida; Kenji Notohara
Journal:  J Gastroenterol       Date:  2006-11-09       Impact factor: 6.772

4.  Prolonged Survival in a Case of Chemotherapy-Sensitive Gastric Cancer That Produced Alpha-Fetoprotein and Protein Induced by Vitamin K Antagonist-II.

Authors:  Naotaka Ogasawara; Emiko Takahashi; Tomoko Matsumoto; Manami Amaike; Mako Nohara; Kazuhiro Nagao; Masahide Ebi; Yasushi Funaki; Makoto Sasaki; Kunio Kasugai
Journal:  Case Rep Gastroenterol       Date:  2015-04-24
  4 in total

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