Literature DB >> 15896965

Synthesis of 2,4,6-trisubstituted pyrimidines as antimalarial agents.

Anu Agarwal1, Kumkum Srivastava, S K Puri, Prem M S Chauhan.   

Abstract

A series of 2,4,6-trisubstituted-pyrimidines were synthesized and evaluated for their in vitro antimalarial activity against Plasmodium falciparum. Of the 18 compounds synthesized, 14 compounds have shown MIC in the range of 0.25-2 microg/mL. These compounds are in vitro severalfold more active than pyrimethamine.

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Year:  2005        PMID： 15896965     DOI： 10.1016/j.bmc.2005.04.061

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  14 in total

1.  One-pot synthesis of tetrazolo[1,5-a]pyrimidines under solvent-free conditions.

Authors:  Ramin Ghorbani-Vaghei; Zahra Toghraei-Semiromi; Mostafa Amiri; Rahman Karimi-Nami
Journal:  Mol Divers       Date:  2013-03-30       Impact factor: 2.943

2.  Microwave synthesis and antimalarial screening of novel 4-amino benzoic acid (PABA)-substituted pyrimidine derivatives as Plasmodium falciparum dihydrofolate reductase inhibitors.

Authors:  Ayesha Aktar Khanam Choudhury; Sathishkumar Vinayagam; Nayana Adhikari; Surajit Kumar Ghosh; Kamaraj Sattu
Journal:  3 Biotech       Date:  2022-07-13       Impact factor: 2.893

3.  O(2)-dependent efficacy of novel piperidine- and piperazine-based chalcones against the human parasite Giardia intestinalis.

Authors:  Vijay Bahadur; Daniela Mastronicola; Hemandra Kumar Tiwari; Yogesh Kumar; Micol Falabella; Leopoldo Paolo Pucillo; Paolo Sarti; Alessandro Giuffrè; Brajendra Kumar Singh
Journal:  Antimicrob Agents Chemother       Date:  2013-11-11       Impact factor: 5.191

4.  Synthesis and antimicrobial evaluation of novel 4-amino-6-(1,3,4-oxadiazolo/1,3,4-thiadiazolo)-pyrimidine derivatives.

Authors:  Poornima Shetty; B M Praveen; M Raghavendra; K Manjunath; Srinivas Cheruku
Journal:  Mol Divers       Date:  2015-10-26       Impact factor: 2.943

Review 5.  Significance and biological importance of pyrimidine in the microbial world.

Authors:  Vinita Sharma; Nitin Chitranshi; Ajay Kumar Agarwal
Journal:  Int J Med Chem       Date:  2014-03-23

6.  The crystal structures of two chalcones: (2E)-1-(5-chloro-thio-phen-2-yl)-3-(2-methyl-phen-yl)prop-2-en-1-one and (2E)-1-(anthracen-9-yl)-3-[4-(propan-2-yl)phen-yl]prop-2-en-1-one.

Authors:  Marisiddaiah Girisha; Hemmige S Yathirajan; Jerry P Jasinski; Christopher Glidewell
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2016-07-19

7.  Crystal structure of 2-oxo-2H-chromen-3-yl propano-ate.

Authors:  Eric Ziki; Jules Yoda; Abdoulaye Djandé; Adama Saba; Rita Kakou-Yao
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2016-10-11

8.  Crystal structure of 2-oxo-2H-chromen-3-yl 4-chloro-benzoate and Hirshfeld surface analysis.

Authors:  Eric Ziki; Siaka Sosso; Frédérica Mansilla-Koblavi; Abdoulaye Djandé; Rita Kakou-Yao
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2017-01-01

9.  (2E)-3-[4-(Benz-yloxy)phen-yl]-1-(pyridin-3-yl)prop-2-en-1-one.

Authors:  Hoong-Kun Fun; Ching Kheng Quah; Prakash S Nayak; B Narayana; B K Sarojini
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-08-15

10.  Synthesis of novel dopamine derived multidirectional ligands from cyanuric chloride: structural and antimicrobial studies.

Authors:  Ziya Erdem Koç; Mustafa Onur Aladag; Ahmet Uysal
Journal:  EXCLI J       Date:  2013-05-07       Impact factor: 4.068
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