| Literature DB >> 15896964 |
Xueqing Wang1, Pramila A Bhatia, Jerome F Daanen, Steve P Latsaw, Jeffrey Rohde, Teodozyi Kolasa, Ahmed A Hakeem, Mark A Matulenko, Masaki Nakane, Marie E Uchic, Loan N Miller, Renjie Chang, Robert B Moreland, Jorge D Brioni, Andrew O Stewart.
Abstract
A series of 3-aryl piperidine analogs with 2-piperidinoalkylamino or 2-piperidinoalkyloxy fused bicyclic rings were prepared and found to be potent and efficacious human dopamine D4 agonists. The synthesis and structure-activity relationship (SAR) studies that led to the identification of these compounds are discussed.Entities:
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Year: 2005 PMID： 15896964 DOI： 10.1016/j.bmc.2005.04.060
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641