| Literature DB >> 15896960 |
György T Balogh1, Krisztina Vukics, Arpád Könczöl, Agnes Kis-Varga, Anikó Gere, János Fischer.
Abstract
Synthesis of nitrone derivatives of trolox is described. Their biological evaluation was performed in vitro for scavenging different free radicals, inhibiting Fe(2+)-induced lipid peroxidation, and in vivo in a permanent middle cerebral artery occlusion model in mice. New compounds exert pharmacological activities comparable to or better than those of trolox or nitrone-type reference compounds.Entities:
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Year: 2005 PMID： 15896960 DOI： 10.1016/j.bmcl.2005.04.043
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823