Literature DB >> 15896873

Production of vaccines against leading biowarfare toxins can utilize DNA scientific technology.

John L Middlebrook1.   

Abstract

There are a significant number of different natural toxins that are potential biological warfare agents against which a vaccine is needed. DNA science has been a key to the development of potential vaccines against the top threat toxin and should contribute such effects for other toxin's vaccines. Several different DNA technological scientific techniques have been used to accomplish the general goals of (1) cloning of the toxin or large toxin fragments, (2) altering the specific gene sequence to obtain high level expression of vaccine candidate production in alternate species (3) placement of the vaccine gene in very different presentation types of species.

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Year:  2005        PMID: 15896873     DOI: 10.1016/j.addr.2005.01.016

Source DB:  PubMed          Journal:  Adv Drug Deliv Rev        ISSN: 0169-409X            Impact factor:   15.470


  7 in total

1.  Generation of high-titer neutralizing antibodies against botulinum toxins A, B, and E by DNA electrotransfer.

Authors:  C Trollet; Y Pereira; A Burgain; E Litzler; M Mezrahi; J Seguin; M Manich; M R Popoff; D Scherman; P Bigey
Journal:  Infect Immun       Date:  2009-02-23       Impact factor: 3.441

2.  Enhanced potency of replicon vaccine using one vector to simultaneously co-express antigen and interleukin-4 molecular adjuvant.

Authors:  Yao Ma; Huai-Jie An; Xiao-Qi Wei; Qing Xu; Yun-Zhou Yu; Zhi-Wei Sun
Journal:  Hum Vaccin Immunother       Date:  2013-01-04       Impact factor: 3.452

3.  Co-administration of antigen with chemokine MCP-3 or MDC/CCL22 enhances DNA vaccine potency.

Authors:  Xinmei Xie; Lin Wang; Wenliang Yang; Ruishuang Yu; Qingli Li; Xiaobin Pang
Journal:  Invest New Drugs       Date:  2015-05-09       Impact factor: 3.850

4.  Production and evaluation of a recombinant subunit vaccine against botulinum neurotoxin serotype B using a 293E expression system.

Authors:  YunZhou Yu; DanYang Shi; Si Liu; Zheng-Wei Gong; Shuang Wang; ZhiWei Sun
Journal:  Hum Vaccin Immunother       Date:  2015       Impact factor: 3.452

5.  DNA electroporation in rabbits as a method for generation of high-titer neutralizing antisera: examples of the botulinum toxins types A, B, and E.

Authors:  Aurore Burgain; Alice Rochard; Capucine Trollet; Christelle Mazuet; Michel R Popoff; Virginie Escriou; Daniel Scherman; Pascal Bigey
Journal:  Hum Vaccin Immunother       Date:  2013-07-22       Impact factor: 3.452

6.  Evaluation of a recombinant Hc of Clostridium botulinum neurotoxin serotype F as an effective subunit vaccine.

Authors:  Yun-Zhou Yu; Na Li; Rui-Lin Wang; Heng-Qi Zhu; Shuang Wang; Wei-Yuan Yu; Zhi-Wei Sun
Journal:  Clin Vaccine Immunol       Date:  2008-10-08

7.  Pentavalent replicon vaccines against botulinum neurotoxins and tetanus toxin using DNA-based Semliki Forest virus replicon vectors.

Authors:  Yun-Zhou Yu; Si Liu; Yao Ma; Zheng-Wei Gong; Shuang Wang; Zhi-Wei Sun
Journal:  Hum Vaccin Immunother       Date:  2014       Impact factor: 3.452

  7 in total

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