| Literature DB >> 15896841 |
Severine Loisel1, Karine Le Ster, Isabelle Quintin-Roue, Jacques-Olivier Pers, Anne Bordron, Pierre Youinou, Christian Berthou.
Abstract
We have developed a novel murine model for B-CLL by engrafting human prolymphocytic leukemia (PLL) or B-CLL cell line cells (JVM-3 and MEC-2 cell lines, respectively) into nude mice. Not only treatment of the mice was a prerequisite for the success of the graft, but also for the first time, females appeared to accept the cells more easily than males. Surprisingly, tumoral murine models for B-CLL could be established with PLL cells but not with B-CLL cells. JVM-3 cells were efficiently transplanted into nude mice through subcutaneous or intravenous routes. Irradiated female mice appeared to be the optimal recipients for tumor growth. Such murine models for human B-CLL may help the development of therapeutic agents.Entities:
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Year: 2005 PMID： 15896841 DOI： 10.1016/j.leukres.2005.04.017
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156