| Literature DB >> 15896743 |
Ronald C Conaway1, Shigeo Sato, Chieri Tomomori-Sato, Tingting Yao, Joan W Conaway.
Abstract
Mediator is an essential component of the RNA polymerase II general transcriptional machinery and plays a crucial part in the activation and repression of eukaryotic mRNA synthesis. The Saccharomyces cerevisiae Mediator was the first to be defined and is a high molecular mass complex composed of >20 distinct subunits that performs multiple activities in transcription. Recent studies have defined the subunit composition and associated activities of mammalian Mediator, and revealed a striking evolutionary conservation of Mediator structure and function from yeast to man.Entities:
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Year: 2005 PMID： 15896743 DOI： 10.1016/j.tibs.2005.03.002
Source DB: PubMed Journal: Trends Biochem Sci ISSN： 0968-0004 Impact factor: 13.807