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Literature DB >> 15896737

Deoxyribonucleoside kinases: two enzyme families catalyze the same reaction.

Abstract

Mammals have four deoxyribonucleoside kinases, the cytoplasmic (TK1) and mitochondrial (TK2) thymidine kinases, and the deoxycytidine (dCK) and deoxyguanosine (dGK) kinases, which salvage the precursors for nucleic acids synthesis. In addition to the native deoxyribonucleoside substrates, the kinases can phosphorylate and thereby activate a variety of anti-cancer and antiviral prodrugs. Recently, the crystal structure of human TK1 has been solved and has revealed that enzymes with fundamentally different origins and folds catalyze similar, crucial cellular reactions.

Entities: Chemical Disease Gene Species

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Year: 2005 PMID： 15896737 DOI： 10.1016/j.tibs.2005.03.003

Source DB: PubMed Journal: Trends Biochem Sci ISSN： 0968-0004 Impact factor: 13.807

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Cited

15 in total

1. Molecular Strategies of Deoxynucleotide Triphosphate Supply Inhibition Used in the Treatment of Gynecologic Malignancies.

Authors: Charles A Kunos; Tomas Radivoyevitch
Journal: Gynecol Obstet (Sunnyvale) Date: 2011-12-10

2. Deoxynucleoside salvage facilitates DNA repair during ribonucleotide reductase blockade in human cervical cancers.

Authors: Charles A Kunos; Gina Ferris; Natalie Pyatka; John Pink; Tomas Radivoyevitch
Journal: Radiat Res Date: 2011-07-14 Impact factor: 2.841

3. The phylogenetic distribution and evolution of enzymes within the thymidine kinase 2-like gene family in metazoa.

Authors: Anke Konrad; Jason Lai; Zeeshan Mutahir; Jure Piškur; David A Liberles
Journal: J Mol Evol Date: 2014-02-06 Impact factor: 2.395

4. Reduced level of ribonucleotide reductase R2 subunits increases dependence on homologous recombination repair of cisplatin-induced DNA damage.

Authors: Z Ping Lin; Yashang Lee; Fang Lin; Michael F Belcourt; Peining Li; Joseph G Cory; Peter M Glazer; Alan C Sartorelli
Journal: Mol Pharmacol Date: 2011-08-29 Impact factor: 4.436

5. Mutagenesis of non-conserved active site residues improves the activity and narrows the specificity of human thymidine kinase 2.

Authors: Monica L Gerth; Stefan Lutz
Journal: Biochem Biophys Res Commun Date: 2007-01-23 Impact factor: 3.575

6. Plant thymidine kinase 1: a novel efficient suicide gene for malignant glioma therapy.

Authors: Zahidul Khan; Wolfgang Knecht; Mette Willer; Elzbieta Rozpedowska; Peter Kristoffersen; Anders Ranegaard Clausen; Birgitte Munch-Petersen; Per M Almqvist; Zoran Gojkovic; Jure Piskur; Tomas J Ekström
Journal: Neuro Oncol Date: 2010-02-13 Impact factor: 12.300

Deoxyribonucleoside kinases: two enzyme families catalyze the same reaction.

1. Molecular Strategies of Deoxynucleotide Triphosphate Supply Inhibition Used in the Treatment of Gynecologic Malignancies.

2. Deoxynucleoside salvage facilitates DNA repair during ribonucleotide reductase blockade in human cervical cancers.

3. The phylogenetic distribution and evolution of enzymes within the thymidine kinase 2-like gene family in metazoa.

4. Reduced level of ribonucleotide reductase R2 subunits increases dependence on homologous recombination repair of cisplatin-induced DNA damage.

5. Mutagenesis of non-conserved active site residues improves the activity and narrows the specificity of human thymidine kinase 2.

6. Plant thymidine kinase 1: a novel efficient suicide gene for malignant glioma therapy.

7. Cloning, expression, purification and characterization of UMP kinase from Staphylococcus aureus.

8. Ribonucleotide reductase inhibition enhances chemoradiosensitivity of human cervical cancers.

9. A Tool for the Import of Natural and Unnatural Nucleoside Triphosphates into Bacteria.

10. Rana grylio virus thymidine kinase gene: an early gene of iridovirus encoding for a cytoplasmic protein.