Literature DB >> 15896308

Expression of Reg/PAP family members during motor nerve regeneration in rat.

Kazuhiko Namikawa1, Munehisa Fukushima, Koichi Murakami, Akinobu Suzuki, Shin Takasawa, Hiroshi Okamoto, Hiroshi Kiyama.   

Abstract

In this study, we examined the expression of mRNAs for Regenerating gene (Reg)/pancreatitis-associated protein (PAP) family members following hypoglossal nerve injury in rats. In addition to four rat family members (RegI, Reg-2/PAP I, PAP II, and PAP III) that had been identified, we newly cloned and sequenced a type-IV Reg gene in rats. Among these five family members, the expression of Reg-2/PAP I mRNA was predominantly enhanced in injured motor neurons after axotomy. Furthermore, a marked induction of PAP III mRNA was observed in the distal part of the injured nerve. A polyclonal antibody was raised against PAP III, and a Western blotting analysis using this antibody confirmed an increased level of PAP III protein in the injured nerve. These results suggest that Reg family members would be new mediators among injured neurons and glial cells, and may play pivotal roles during nerve regeneration.

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Year:  2005        PMID： 15896308     DOI： 10.1016/j.bbrc.2005.04.105

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  16 in total

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Journal:  Ann Clin Transl Neurol       Date:  2014-10-09       Impact factor: 4.511
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