Literature DB >> 15896290

Is NF-kappaB a culprit in type 2 diabetes?

Fei Chen1.   

Abstract

It has been generally viewed that salicylates ameliorate type 2 diabetes through interfering with the NF-kappaB signaling. Earlier studies indicated that IKKbeta was the key for the development of insulin resistance. However, it was unknown whether IKKbeta itself, or its downstream target, NF-kappaB, plays major roles in insulin resistance. New data suggest that NF-kappaB and NF-kappaB-regulated cytokines are crucial for the diabetogenesis.

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Year:  2005        PMID： 15896290     DOI： 10.1016/j.bbrc.2005.03.075

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  7 in total

1.  Liver kinase B1 suppresses lipopolysaccharide-induced nuclear factor κB (NF-κB) activation in macrophages.

Authors:  Zhaoyu Liu; Wencheng Zhang; Miao Zhang; Huaiping Zhu; Cate Moriasi; Ming-Hui Zou
Journal:  J Biol Chem       Date:  2014-12-01       Impact factor: 5.157

2.  Cichorium intybus attenuates Streptozotocin-induced pancreatic β-cell damage by inhibiting NF-κB activation and oxidative stress.

Authors:  Ramya Devi Kt; Nageswaran Sivalingam
Journal:  J Appl Biomed       Date:  2020-08-12       Impact factor: 1.797

3.  Inferring genome-wide functional modulatory network: a case study on NF-κB/RelA transcription factor.

Authors:  Xueling Li; Min Zhu; Allan R Brasier; Andrzej S Kudlicki
Journal:  J Comput Biol       Date:  2015-04       Impact factor: 1.549

4.  BRD7 plays an anti-inflammatory role during early acute inflammation by inhibiting activation of the NF-кB signaling pathway.

Authors:  Ran Zhao; Yukun Liu; Heran Wang; Jing Yang; Weihong Niu; Songqing Fan; Wei Xiong; Jian Ma; Xiaoling Li; Joshua B Phillips; Ming Tan; Yuanzheng Qiu; Guiyuan Li; Ming Zhou
Journal:  Cell Mol Immunol       Date:  2016-07-04       Impact factor: 11.530

5.  A New Paradigm to Mitigate Osteosarcoma by Regulation of MicroRNAs and Suppression of the NF-κB Signaling Cascade.

Authors:  Raj Kumar Mongre; Simrinder Singh Sodhi; Mrinmoy Ghosh; Jeong Hyun Kim; Nameun Kim; Neelesh Sharma; Dong Kee Jeong
Journal:  Dev Reprod       Date:  2014-12

6.  Effect of Cichorium intybus L. on the expression of hepatic NF-κB and IKKβ and serum TNF-α in STZ- and STZ+ niacinamide-induced diabetes in rats.

Authors:  Lotfollah Rezagholizadeh; Yasin Pourfarjam; Azin Nowrouzi; Manuchehr Nakhjavani; Alipasha Meysamie; Nasrin Ziamajidi; Peyman S Nowrouzi
Journal:  Diabetol Metab Syndr       Date:  2016-02-13       Impact factor: 3.320

7.  Antidiabetic, Antihyperlipidemic, Antioxidant, Anti-inflammatory Activities of Ethanolic Seed Extract of Annona reticulata L. in Streptozotocin Induced Diabetic Rats.

Authors:  Wenbin Wen; Yukiat Lin; Zhenyu Ti
Journal:  Front Endocrinol (Lausanne)       Date:  2019-10-23       Impact factor: 5.555
  7 in total

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