Literature DB >> 15895531

Deoxyverrucosidin, a novel GRP78/BiP down-regulator, produced by Penicillium sp.

Soo-Jin Choo1, Hae-Ryong Park, In-Ja Ryoo, Jong-Pyung Kim, Bong-Sik Yun, Chang-Jin Kim, Kazuo Shin-ya, Ick-Dong Yoo.   

Abstract

Glucose-regulated protein 78 (GRP78) resides in endoplasmic reticulum (ER) and plays a role in protecting tumor cells against the toxic effects of anticancer agents. During the search for down-regulators of GRP78 using a reporter gene (luciferase) assay system, we isolated a novel compound designated as deoxyverrucosidin (1), a congener of verrucosidin (2), from Penicillium sp. and identified it as a down-regulator of the grp78 gene. The structure of 1 was determined by mainly ESI-mass and two-dimensional NMR spectra. 1 dose-dependently inhibited the expression of GRP78 promoter with an IC50 of 30 nM.

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Year:  2005        PMID： 15895531     DOI： 10.1038/ja.2005.26

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  10 in total

1.  Verrucosidin Derivatives from the Deep Sea Cold-Seep-Derived Fungus Penicillium polonicum CS-252.

Authors:  Yanhe Li; Xiaoming Li; Xin Li; Suiqun Yang; Bingui Wang; Honglei Li
Journal:  Int J Mol Sci       Date:  2022-05-16       Impact factor: 6.208

2.  Penicyrones A and B, an epimeric pair of α-pyrone-type polyketides produced by the marine-derived Penicillium sp.

Authors:  Ying-Yue Bu; Hiroyuki Yamazaki; Ohgi Takahashi; Ryota Kirikoshi; Kazuyo Ukai; Michio Namikoshi
Journal:  J Antibiot (Tokyo)       Date:  2015-08-05       Impact factor: 2.649

3.  Role of GRP78/BiP degradation and ER stress in deoxynivalenol-induced interleukin-6 upregulation in the macrophage.

Authors:  Yuhui Shi; Katie Porter; Narayanan Parameswaran; Hee Kyong Bae; James J Pestka
Journal:  Toxicol Sci       Date:  2009-03-31       Impact factor: 4.849

4.  Metabolomic and Transcriptomic Comparison of Solid-State and Submerged Fermentation of Penicillium expansum KACC 40815.

Authors:  Hyang Yeon Kim; Do Yeon Heo; Hye Min Park; Digar Singh; Choong Hwan Lee
Journal:  PLoS One       Date:  2016-02-10       Impact factor: 3.240

Review 5.  The Unfolded Protein Response in Breast Cancer.

Authors:  Eoghan P McGrath; Susan E Logue; Katarzyna Mnich; Shane Deegan; Richard Jäger; Adrienne M Gorman; Afshin Samali
Journal:  Cancers (Basel)       Date:  2018-09-21       Impact factor: 6.639

Review 6.  Natural Polypropionates in 1999-2020: An Overview of Chemical and Biological Diversity.

Authors:  Zhaoming Liu; Hongxin Liu; Weimin Zhang
Journal:  Mar Drugs       Date:  2020-11-19       Impact factor: 5.118

7.  Exploring Verrucosidin Derivatives with Glucose-Uptake-Stimulatory Activity from Penicillium cellarum Using MS/MS-Based Molecular Networking.

Authors:  Junjie Han; Baosong Chen; Rui Zhang; Jinjin Zhang; Huanqin Dai; Tao Wang; Jingzu Sun; Guoliang Zhu; Wei Li; Erwei Li; Xueting Liu; Wenbing Yin; Hongwei Liu
Journal:  J Fungi (Basel)       Date:  2022-01-30

8.  Repositioning of Verrucosidin, a purported inhibitor of chaperone protein GRP78, as an inhibitor of mitochondrial electron transport chain complex I.

Authors:  Simmy Thomas; Natasha Sharma; Reyna Gonzalez; Peng-Wen Pao; Florence M Hofman; Thomas C Chen; Stan G Louie; Michael C Pirrung; Axel H Schönthal
Journal:  PLoS One       Date:  2013-06-06       Impact factor: 3.240

Review 9.  Endoplasmic reticulum stress: its role in disease and novel prospects for therapy.

Authors:  Axel H Schönthal
Journal:  Scientifica (Cairo)       Date:  2012-12-23

10.  An Unusual Conformational Isomer of Verrucosidin Backbone from a Hydrothermal Vent Fungus, Penicillium sp. Y-50-10.

Authors:  Chengqian Pan; Yutong Shi; Bibi Nazia Auckloo; Xuegang Chen; Chen-Tung Arthur Chen; Xinyi Tao; Bin Wu
Journal:  Mar Drugs       Date:  2016-08-18       Impact factor: 5.118
  10 in total

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