| Literature DB >> 15895530 |
Yukiko Umeda1, Shuhei Chijiwa, Kazuo Furihata, Keiko Furihata, Shohei Sakuda, Hiromichi Nagasawa, Hidenori Watanabe, Kazuo Shin-ya.
Abstract
In the course of our screening program for regulators of a molecular chaperone GRP78 expression, we isolated a novel inhibitor of GRP78 expression, designated as prunustatin A, from Streptomyces violaceoniger 4521-SVS3. The structure of prunustatin A was determined by a series of NMR analyses to be an oxidized type of the neoantimycin family. Prunustatin A inhibited the expression of GRP78 induced by 2-deoxyglucose in human fibrosarcoma HT1080 cells accompanied by global cell death without showing cytotoxicity under normal nutrient condition.Entities:
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Year: 2005 PMID： 15895530 DOI： 10.1038/ja.2005.25
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649