| Literature DB >> 15895524 |
Simon J Shaw1, Darren Abbanat, Gary W Ashley, Karen Bush, Barbara Foleno, Mark Macielag, Dan Zhang, David C Myles.
Abstract
An array of 15-amido substituted erythromycin A compounds was synthesized using a chemobiosynthesis approach. It was found that while the in vitro antibacterial activities of aryl amides were inferior to erythromycin A, substituted benzylamides showed equivalent and in some cases improved activity against the macrolide-resistant strains. The 15-amidoerythromycins represent a new class of antibacterial macrolides.Entities:
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Year: 2005 PMID： 15895524 DOI： 10.1038/ja.2005.19
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649