| Literature DB >> 15895422 |
Daniela Berg1, Marc Niwar, Sylvia Maass, Alexander Zimprich, J Carsten Möller, Ullrich Wuellner, Tanja Schmitz-Hübsch, Christine Klein, Eng-King Tan, Ludger Schöls, Laura Marsh, Ted M Dawson, Bernd Janetzky, Thomas Müller, Dirk Woitalla, Vladimir Kostic, Peter P Pramstaller, Wolfgang H Oertel, Peter Bauer, Rejko Krueger, Thomas Gasser, Olaf Riess.
Abstract
Data on the frequency of alpha-synuclein mutations in Parkinson's disease (PD) are limited. Screening the entire coding region in 1,921 PD patients with denaturing high performance liquid chromatography and subsequent sequencing we only detected silent mutations (g.2654A>G, g.10151G>A, and g.15986A>T) and the c.209G>A substitution corresponding to the p.A53T mutation. These results demonstrate that mutations in the alpha-synuclein gene are rare and suggest that other factors contribute to alpha-synuclein aggregation in the majority of PD patients. (c) 2005 Movement Disorder Society.Entities:
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Year: 2005 PMID： 15895422 DOI： 10.1002/mds.20504
Source DB: PubMed Journal: Mov Disord ISSN： 0885-3185 Impact factor: 10.338