OBJECTIVES: To test the hypotheses that (1) people with neuromuscular disease (NMD) have multiple risk factors for cardiovascular disease and diabetes and (2) these risk factors worsen over time. DESIGN: Longitudinal testing with average 2.5-year follow-up. SETTING: Human performance laboratory of a university. PARTICIPANTS: Eleven ambulatory volunteers with slowly progressive NMD and 8 able-bodied controls, group-matched for age and body mass index (BMI) at baseline. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Percentage of body fat (%BF), physical activity, energy expenditure, blood lipids and glucose, and blood pressure. RESULTS: At baseline, NMD subjects were more obese (37%BF vs 34%BF, respectively) and more sedentary than the controls, spending less time in total activity (144 min/d vs 214 min/d) and in exercise (11 min/d vs 45 min/d). The NMD group also had numerous cardiovascular and metabolic risk factors, with low high-density lipoprotein cholesterol, high BMI, and high triglyceride being the most common. Additionally, 55% of the NMD group satisfied the criteria for metabolic syndrome, versus 0% in the control group. Most parameters did not significantly worsen during the average 2.5-year follow-up period in either group. CONCLUSIONS: People with NMD are at high risk for developing chronic diseases resulting from obesity and a sedentary lifestyle. Intervention studies aimed at reducing their risk for such chronic diseases are warranted.
OBJECTIVES: To test the hypotheses that (1) people with neuromuscular disease (NMD) have multiple risk factors for cardiovascular disease and diabetes and (2) these risk factors worsen over time. DESIGN: Longitudinal testing with average 2.5-year follow-up. SETTING:Human performance laboratory of a university. PARTICIPANTS: Eleven ambulatory volunteers with slowly progressive NMD and 8 able-bodied controls, group-matched for age and body mass index (BMI) at baseline. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Percentage of body fat (%BF), physical activity, energy expenditure, blood lipids and glucose, and blood pressure. RESULTS: At baseline, NMD subjects were more obese (37%BF vs 34%BF, respectively) and more sedentary than the controls, spending less time in total activity (144 min/d vs 214 min/d) and in exercise (11 min/d vs 45 min/d). The NMD group also had numerous cardiovascular and metabolic risk factors, with low high-density lipoprotein cholesterol, high BMI, and high triglyceride being the most common. Additionally, 55% of the NMD group satisfied the criteria for metabolic syndrome, versus 0% in the control group. Most parameters did not significantly worsen during the average 2.5-year follow-up period in either group. CONCLUSIONS:People with NMD are at high risk for developing chronic diseases resulting from obesity and a sedentary lifestyle. Intervention studies aimed at reducing their risk for such chronic diseases are warranted.
Authors: Gabrielle A Donlevy; Sarah P Garnett; Kayla M D Cornett; Marnee J McKay; Jennifer N Baldwin; Rosemary R Shy; Sabrina W Yum; Timothy Estilow; Isabella Moroni; Maria Foscan; Emanuela Pagliano; Davide Pareyson; Matilde Laura; Trupti Bhandari; Francesco Muntoni; Mary M Reilly; Richard S Finkel; Janet E Sowden; Katy J Eichinger; David N Herrmann; Michael E Shy; Joshua Burns; Manoj P Menezes Journal: Neurology Date: 2021-09-07 Impact factor: 9.910
Authors: Mindy Dopler Nelson; Lana M Widman; Richard Ted Abresch; Kimber Stanhope; Peter J Havel; Dennis M Styne; Craig M McDonald Journal: J Spinal Cord Med Date: 2007 Impact factor: 1.985