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Literature DB >> 15894488

Plasma free amino acid profile in cancer patients.

Hong-Shiee Lai¹, Jenq-Chang Lee, Po-Huang Lee, Shan-Tair Wang, Wei-Jao Chen.

Abstract

Redistribution or translocation of plasma free amino acids (PFAAs) to support visceral or tumor protein synthesis is an essential feature in cancer patients. An abnormal PFAA profile might be presented via the total reflection of cancer-induced protein metabolism in tumors, skeletal muscle and the liver in cancer patients. Clinical data from 13 studies have demonstrated a cancer-related PFAA profile, especially in digestive organ cancers. The PFAA profile can differ between the early and late stages of cancer. The profile is also affected by the type of cancer. Therefore, it is postulated that a detailed analysis of the PFAA profile may serve as one of the biological markers for cancer patients.

Entities: Disease Species

Mesh：

Substances：
Amino Acids

Year: 2005 PMID： 15894488 DOI： 10.1016/j.semcancer.2005.04.003

Source DB: PubMed Journal: Semin Cancer Biol ISSN： 1044-579X Impact factor: 15.707

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Cited

45 in total

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4. Plasma free amino acid profiling of esophageal cancer using high-performance liquid chromatography spectroscopy.

Authors: Hong Ma; Ayshamgul Hasim; Batur Mamtimin; Bin Kong; Hai-Ping Zhang; Ilyar Sheyhidin
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5. Major surgery diminishes systemic arginine availability and suppresses nitric oxide response to feeding in patients with early stage breast cancer.

Authors: Mariëlle P K J Engelen; V Suzanne Klimberg; Arianna Allasia; Nicolaas E P Deutz
Journal: Clin Nutr Date: 2017-08-05 Impact factor: 7.324

Plasma free amino acid profile in cancer patients.

1. Revealing the metabonomic variation of EC using ¹H-NMR spectroscopy and its association with the clinicopathological characteristics.

2. (1)H-NMR-based metabolomics of tumor tissue for the metabolic characterization of rat hepatocellular carcinoma formation and metastasis.

3. Amino acid profile index for early detection of endometrial cancer: verification as a novel diagnostic marker.

4. Plasma free amino acid profiling of esophageal cancer using high-performance liquid chromatography spectroscopy.

5. Major surgery diminishes systemic arginine availability and suppresses nitric oxide response to feeding in patients with early stage breast cancer.

6. Metabolomics approach for predicting response to neoadjuvant chemotherapy for breast cancer.

7. Targeted metabolic profiling of hepatocellular carcinoma and hepatitis C using LC-MS/MS.

8. Metabolomics analysis in pterygium tissue.

9. Plasma metabolomic profiles in breast cancer patients and healthy controls: by race and tumor receptor subtypes.

10. Biomarker Analyses in Patients With Advanced Solid Tumors Treated With the LAT1 Inhibitor JPH203.