| Literature DB >> 1589443 |
M R Naidu1, U N Das, A Kishan.
Abstract
In vitro and in vivo studies have shown that gamma-linoleic acid (GLA), arachidonic acid (AA) and eicosapentaenoic acid (EPA) can selectively kill tumor cells. In a clinical trial, the effectiveness of intratumoral administration of GLA in patients with gliomas was studied. Of the 6 patients treated, all showed substantial response to GLA as documented by computerized tomography. There were no acute side-effects due to the therapy. This report demonstrates that intratumoral administration of GLA is a possible approach to the treatment of human glial tumors.Entities:
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Year: 1992 PMID： 1589443 DOI： 10.1016/0952-3278(92)90110-5
Source DB: PubMed Journal: Prostaglandins Leukot Essent Fatty Acids ISSN： 0952-3278 Impact factor: 4.006