| Literature DB >> 15894108 |
Ilja Striz1, Eliska Krasna, Krasna Eliska, Eva Honsova, Honsova Eva, Jiri Lacha, Lacha Jiri, Katerina Petrickova, Petrickova Katerina, Marcela Jaresova, Jaresova Marcela, Alena Lodererova, Lodererova Alena, Radka Bohmova, Bohmova Radka, Sarka Valhova, Valhova Sarka, Antonij Slavcev, Slavcev Antonij, Stefan Vitko, Vitko Stefan.
Abstract
Interleukin 18 (IL-18) is a potent proinflammatory cytokine involved in the host defence by upregulating both innate and acquired immune responses and may be of particular importance also in mechanisms of kidney allograft rejection. Immunohistochemical staining of protocol biopsies showed constitutive IL-18 expression in the epithelium of distal tubules with the induction of immunoreactivity in acute rejection patients where also proximal tubules, infiltrating leukocytes, and endothelium were strongly positive. Furthermore, serum levels of IL-18 were significantly elevated in patients with acute rejection of kidney allograft (1247+/-389 pg/l) as compared to patients with uncomplicated outcome of kidney transplantation (444+/-164 pg/l) and subjects with acute tubulointerstitial nephropathy (385+/-155 pg/l, p<0.0001 for both comparisons). Tissue culture model of renal epithelial cells expressed IL-18 mRNA constitutively and released mature IL-18 in response to TNF-alpha and IFN-gamma. We assume that upregulation of epithelial IL-18 plays an important role in immune and immunopathological reactions in renal parenchyma and contributes to rejection mechanisms of kidney allograft.Entities:
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Year: 2005 PMID： 15894108 DOI： 10.1016/j.imlet.2005.01.010
Source DB: PubMed Journal: Immunol Lett ISSN： 0165-2478 Impact factor: 3.685