Literature DB >> 15893929

Beta-lactam compounds as apparently uncompetitive inhibitors of HIV-1 protease.

Tamás Sperka1, János Pitlik, Péter Bagossi, József Tözsér.   

Abstract

Compounds of a combinatorial monocyclic beta-lactam library were found to be apparently uncompetitive inhibitors of HIV-1 protease, providing lead compounds for a new class of HIV protease inhibitors.

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Year:  2005        PMID： 15893929     DOI： 10.1016/j.bmcl.2005.04.020

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  17 in total

1.  Identification of broad-based HIV-1 protease inhibitors from combinatorial libraries.

Authors:  Max W Chang; Michael J Giffin; Rolf Muller; Jeremiah Savage; Ying C Lin; Sukwon Hong; Wei Jin; Landon R Whitby; John H Elder; Dale L Boger; Bruce E Torbett
Journal:  Biochem J       Date:  2010-08-01       Impact factor: 3.857

Review 2.  Targeting structural flexibility in HIV-1 protease inhibitor binding.

Authors:  Viktor Hornak; Carlos Simmerling
Journal:  Drug Discov Today       Date:  2006-12-20       Impact factor: 7.851

3.  Solution kinetics measurements suggest HIV-1 protease has two binding sites for darunavir and amprenavir.

Authors:  Andrey Y Kovalevsky; Arun K Ghosh; Irene T Weber
Journal:  J Med Chem       Date:  2008-09-20       Impact factor: 7.446

4.  Ultra-high resolution crystal structure of HIV-1 protease mutant reveals two binding sites for clinical inhibitor TMC114.

Authors:  Andrey Y Kovalevsky; Fengling Liu; Sofiya Leshchenko; Arun K Ghosh; John M Louis; Robert W Harrison; Irene T Weber
Journal:  J Mol Biol       Date:  2006-08-04       Impact factor: 5.469

5.  A Direct Interaction with RNA Dramatically Enhances the Catalytic Activity of the HIV-1 Protease In Vitro.

Authors:  Marc Potempa; Ellen Nalivaika; Debra Ragland; Sook-Kyung Lee; Celia A Schiffer; Ronald Swanstrom
Journal:  J Mol Biol       Date:  2015-05-15       Impact factor: 5.469

Review 6.  Targeting Phenotypically Tolerant Mycobacterium tuberculosis.

Authors:  Ben Gold; Carl Nathan
Journal:  Microbiol Spectr       Date:  2017-01

7.  Novel macromolecular inhibitors of human immunodeficiency virus-1 protease.

Authors:  Gabriella Miklóssy; József Tözsér; János Kádas; Rieko Ishima; John M Louis; Péter Bagossi
Journal:  Protein Eng Des Sel       Date:  2008-05-13       Impact factor: 1.650

8.  Synthesis and antimicrobial activities of some novel diastereoselective monocyclic cis-β-lactams using 2-ethoxy carbonyl DCPN as a carboxylic acid activator.

Authors:  Mahesh Kumar Mishra; Vedeshwar Narayan Singh; Khursheed Ahmad; Sitaram Sharma
Journal:  Mol Divers       Date:  2020-05-13       Impact factor: 2.943

Review 9.  Isocyanide-based multicomponent reactions towards cyclic constrained peptidomimetics.

Authors:  Gijs Koopmanschap; Eelco Ruijter; Romano Va Orru
Journal:  Beilstein J Org Chem       Date:  2014-03-04       Impact factor: 2.883

10.  Diversity-oriented synthesis and activity evaluation of substituted bicyclic lactams as anti-malarial against Plasmodium falciparum.

Authors:  Vijeta Sharma; Shalini Agarwal; Sanjay M Madurkar; Gaurav Datta; Poonam Dangi; Ramu Dandugudumula; Subhabrata Sen; Shailja Singh
Journal:  Malar J       Date:  2014-11-28       Impact factor: 2.979
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