Literature DB >> 15893879

Regulation of SNARK activity in response to cellular stresses.

Diana L Lefebvre1, Cheryl F Rosen.   

Abstract

SNARK is a member of the AMPK subfamily of serine/threonine protein kinases. In this study, we examined the regulation of SNARK activity in kidney (BHK, HEK293), pancreatic beta-cell insulinoma (INS-1), hepatocarcinoma (H4IIE) and keratinocyte (NRKC)-derived cell lines in response to diverse cellular stresses. We show that SNARK activity is regulated by glucose- or glutamine-deprivation, induction of endoplasmic reticulum stress by homocysteine or DTT, elevation of cellular AMP and/or depletion of ATP, hyperosmotic stress, salt stress, ultraviolet B radiation and oxidative stress caused by hydrogen peroxide. Moreover, the regulation of SNARK activity in response to cellular stresses depends greatly upon cell type. Furthermore, SNARK activity is downregulated by metformin in a dose- and time-dependent manner in H4IIE cells. These observations support a role for SNARK as a molecular component of the cellular stress response.

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Year:  2005        PMID： 15893879     DOI： 10.1016/j.bbagen.2005.03.015

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  22 in total

1.  The Role of the UNC-82 Protein Kinase in Organizing Myosin Filaments in Striated Muscle of Caenorhabditis elegans.

Authors:  NaTasha R Schiller; Christopher D Duchesneau; Latrisha S Lane; April R Reedy; Emily R Manzon; Pamela E Hoppe
Journal:  Genetics       Date:  2016-12-30       Impact factor: 4.562

2.  The AMPK-related kinase SNARK regulates hepatitis C virus replication and pathogenesis through enhancement of TGF-β signaling.

Authors:  Kaku Goto; Wenyu Lin; Leiliang Zhang; Nikolaus Jilg; Run-Xuan Shao; Esperance A K Schaefer; Hong Zhao; Dahlene N Fusco; Lee F Peng; Naoya Kato; Raymond T Chung
Journal:  J Hepatol       Date:  2013-07-02       Impact factor: 25.083

3.  The AMPK-related kinase SNARK regulates muscle mass and myocyte survival.

Authors:  Sarah J Lessard; Donato A Rivas; Kawai So; Ho-Jin Koh; André Lima Queiroz; Michael F Hirshman; Roger A Fielding; Laurie J Goodyear
Journal:  J Clin Invest       Date:  2016-02       Impact factor: 14.808

4.  Hunk is required for HER2/neu-induced mammary tumorigenesis.

Authors:  Elizabeth S Yeh; Thomas W Yang; Jason J Jung; Heather P Gardner; Robert D Cardiff; Lewis A Chodosh
Journal:  J Clin Invest       Date:  2011-03       Impact factor: 14.808

5.  Caenorhabditis elegans unc-82 encodes a serine/threonine kinase important for myosin filament organization in muscle during growth.

Authors:  Pamela E Hoppe; Johnnie Chau; Kelly A Flanagan; April R Reedy; Lawrence A Schriefer
Journal:  Genetics       Date:  2009-11-09       Impact factor: 4.562

6.  The Snf1-related kinase, Hunk, is essential for mammary tumor metastasis.

Authors:  Gerald B W Wertheim; Thomas W Yang; Tien-chi Pan; Anna Ramne; Zhandong Liu; Heather P Gardner; Katherine D Dugan; Petra Kristel; Bas Kreike; Marc J van de Vijver; Robert D Cardiff; Carol Reynolds; Lewis A Chodosh
Journal:  Proc Natl Acad Sci U S A       Date:  2009-08-28       Impact factor: 11.205

7.  The ubiquitin-associated domain of AMPK-related protein kinases allows LKB1-induced phosphorylation and activation.

Authors:  Mark H Rider
Journal:  Biochem J       Date:  2006-03-15       Impact factor: 3.857

8.  Potential Role of the AMP-activated Protein Kinase in Regulation of Insulin Action.

Authors:  Jonathan S Fisher
Journal:  Cellscience       Date:  2006-01-28

Review 9.  LKB1 and AMP-activated protein kinase control of mTOR signalling and growth.

Authors:  R J Shaw
Journal:  Acta Physiol (Oxf)       Date:  2009-02-19       Impact factor: 6.311

10.  Regulation of skeletal muscle sucrose, non-fermenting 1/AMP-activated protein kinase-related kinase (SNARK) by metabolic stress and diabetes.

Authors:  A Rune; M E Osler; T Fritz; J R Zierath
Journal:  Diabetologia       Date:  2009-08-04       Impact factor: 10.122
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