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Literature DB >> 1589386

Testotoxicosis: gonadotrophin-independent male sexual precocity.

Abstract

In this era of rapidly developing investigational tools and pharmacology, the pathophysiology of precocious puberty is becoming well defined. What was previously thought to be a form of gonadotrophin releasing hormone (GNRH)-dependent central precocious puberty is now classified as GNRH-independent familial testotoxicosis. We present two such cases and review the clinical features, pathophysiology and treatment of testotoxicosis.

Entities: Disease Gene

Mesh：

Substances：
Testosterone

Year: 1992 PMID： 1589386 PMCID： PMC2399261 DOI： 10.1136/pgmj.68.797.225

Source DB: PubMed Journal: Postgrad Med J ISSN： 0032-5473 Impact factor: 2.401

23 in total

1. Familial constitutional precocious puberty in a boy three years of age: report of a case.

Authors: E A MORTIMER
Journal: Pediatrics Date: 1954-02 Impact factor: 7.124

Review 2. Clinical review 14: Pathophysiology and treatment of sexual precocity.

Authors: S L Kaplan; M M Grumbach
Journal: J Clin Endocrinol Metab Date: 1990-10 Impact factor: 5.958

3. Spironolactone and testicular cytochrome P-450: decreased testosterone formation in several species and changes in hepatic drug metabolism.

Authors: R H Menard; B Stripp; J R Gillette
Journal: Endocrinology Date: 1974-06 Impact factor: 4.736

Review 4. Pubertal growth: physiology and pathophysiology.

Authors: G B Cutler; F G Cassorla; J L Ross; O H Pescovitz; K M Barnes; F Comite; P P Feuillan; L Laue; C M Foster; D Kenigsberg
Journal: Recent Prog Horm Res Date: 1986

5. Pituitary gonadotropin-independent male-limited autosomal dominant sexual precocity in nine generations: familial testotoxicosis.

Authors: C A Egli; S M Rosenthal; M M Grumbach; J M Montalvo; B Gondos
Journal: J Pediatr Date: 1985-01 Impact factor: 4.406

Testotoxicosis: gonadotrophin-independent male sexual precocity.

1. Familial constitutional precocious puberty in a boy three years of age: report of a case.

Review 2. Clinical review 14: Pathophysiology and treatment of sexual precocity.

3. Spironolactone and testicular cytochrome P-450: decreased testosterone formation in several species and changes in hepatic drug metabolism.

Review 4. Pubertal growth: physiology and pathophysiology.

5. Pituitary gonadotropin-independent male-limited autosomal dominant sexual precocity in nine generations: familial testotoxicosis.

6. Ketoconazole in the management of precocious puberty not responsive to LHRH-analogue therapy.

7. Short term, low dose estradiol accelerates ulnar growth in boys.

8. A new hypothesis based on suicide substrate inhibitor studies for the mechanism of action of aromatase.

9. Testicular changes in gonadotropin-independent familial male sexual precocity. Familial testotoxicosis.

10. Site of action of low dose ketoconazole on androgen biosynthesis in men.

1. Behavioral aggressiveness in boys with sexual precocity.

2. A Case of Familial Male-Limited Precocious Puberty in a Child With Klinefelter Syndrome.