| Literature DB >> 15893024 |
Kazuhiko Torisu1, Kaoru Kobayashi, Maki Iwahashi, Hiromu Egashira, Yoshihiko Nakai, Yutaka Okada, Fumio Nanbu, Shuichi Ohuchida, Hisao Nakai, Masaaki Toda.
Abstract
A series of N-(p-alkoxy)benzoyl-5-methoxy-2-methylindole-3-acetic acids and N-(p-butoxy)benzoyl-2-methylindole-4-acetic acid were discovered as new chemical leads for a prostaglandin D2 (PGD2) receptor antagonist. Most of them exhibited PGD2 receptor binding and blocked cyclic adenosine 3',5'-monophosphate (cAMP) formation in vitro. In particular, 2-methylindole-4-acetic acid analog 1 showed markedly increased receptor affinity and cAMP antagonist activity. Chemistry and structure activity relationship (SAR) data are also presented.Entities:
Mesh：
Substances：
Year: 2005 PMID： 15893024 DOI： 10.1016/j.ejmech.2004.11.011
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514