Literature DB >> 15892685

Synthesis and pharmacology of new camptothecin drugs.

Russell W Driver1, Li-Xi Yang.   

Abstract

Camptothecin (CPT) drugs exhibit antineoplastic activity against colorectal, breast, lung and ovarian cancers. This review briefly summarizes the pharmacology of CPT drugs, examines four strategies and methods for the synthesis of camptothecins, and finally discusses homocamptothecins and silatecans, two new classes of CPT analog.

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Year:  2005        PMID： 15892685     DOI： 10.2174/1389557053765547

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  5 in total

1.  Structural simplification of bioactive natural products with multicomponent synthesis. 3. Fused uracil-containing heterocycles as novel topoisomerase-targeting agents.

Authors:  Nikolai M Evdokimov; Severine Van Slambrouck; Petra Heffeter; Lee Tu; Benjamin Le Calvé; Delphine Lamoral-Theys; Carla J Hooten; Pavel Y Uglinskii; Snezna Rogelj; Robert Kiss; Wim F A Steelant; Walter Berger; Jeremy J Yang; Cristian G Bologa; Alexander Kornienko; Igor V Magedov
Journal:  J Med Chem       Date:  2011-03-09       Impact factor: 7.446

Review 2.  Perspectives on biologically active camptothecin derivatives.

Authors:  Ying-Qian Liu; Wen-Qun Li; Susan L Morris-Natschke; Keduo Qian; Liu Yang; Gao-Xiang Zhu; Xiao-Bing Wu; An-Liang Chen; Shao-Yong Zhang; Xiang Nan; Kuo-Hsiung Lee
Journal:  Med Res Rev       Date:  2015-03-21       Impact factor: 12.944

3.  Synthesis, Experimental and Density Functional Theory (DFT) Studies on Solubility of Camptothecin Derivatives.

Authors:  Chin-Hung Lai; Chia-Chin Chang; Yi-Lin Weng; Ta-Hsien Chuang
Journal:  Molecules       Date:  2018-12-01       Impact factor: 4.411

4.  Engineering of Peglayted Camptothecin Into Nanomicelles and Supramolecular Hydrogels for Pesticide Combination Control.

Authors:  Zhi-Jun Zhang; Xiao-Fei Shang; Liu Yang; Yan-Bin Shi; Ying-Qian Liu; Jun-Cai Li; Guan-Zhou Yang; Cheng-Jie Yang
Journal:  Front Chem       Date:  2020-01-15       Impact factor: 5.221

5.  A Computational QSAR, Molecular Docking and In Vitro Cytotoxicity Study of Novel Thiouracil-Based Drugs with Anticancer Activity against Human-DNA Topoisomerase II.

Authors:  Doaa M Khaled; Mohamed E Elshakre; Mahmoud A Noamaan; Haider Butt; Marwa M Abdel Fattah; Dalia A Gaber
Journal:  Int J Mol Sci       Date:  2022-10-05       Impact factor: 6.208
  5 in total

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