| Literature DB >> 15892448 |
Tanya L Butler1, Keith R Pennypacker.
Abstract
FRA-2 is involved in cellular differentiation and is also upregulated in response to ischemic injury to the brain. To shed light on the function of this transcription factor, a novel microarray analysis was utilized to identify FRA-2-dependent gene expression increased in the hypoxic response. Genes were identified that were upregulated by exposure of neuronally differentiated PC12 cells to hypoxia. Using a dominant negative construct to block FRA-2, a second subset of genes that were FRA-2 dependent was found. Cross comparison then allowed isolation of a list of genes that were induced in response to hypoxia in a FRA-2-dependent manner. These data suggest that FRA-2 is involved in the transcriptional control of neuroprotective genes and in the switch from aerobic to anaerobic metabolism.Entities:
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Year: 2005 PMID： 15892448 PMCID： PMC6009107 DOI： 10.3727/000000005783992160
Source DB: PubMed Journal: Gene Expr ISSN： 1052-2166