| Literature DB >> 15891087 |
S A Roelens1, V Beck, G Aerts, S Clerens, G Vanden Bergh, L Arckens, V M Darras, S van der Geyten.
Abstract
PCBs are known as neurotoxic compounds. Part of this neurotoxicity could be due to an alteration of the expression of TH-regulated genes in brain. To identify such genes, brain protein extracts of hypo- and hyperthyroid as well as PCB-treated embryos were compared by fluorescent 2D-DIGE. In total, we observed 109 differentially expressed proteins, of which 17 differed with both PCB and hypo- or hyperthyroid treatment. It was found that the interaction of PCBs with the expression of TH-regulated genes is congener-specific and that both hyperthyroidism- and hypothyroidism-related effects occur.Entities:
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Year: 2005 PMID： 15891087 DOI： 10.1196/annals.1327.088
Source DB: PubMed Journal: Ann N Y Acad Sci ISSN： 0077-8923 Impact factor: 5.691