| Literature DB >> 15891009 |
Nicolas Chartrel1, Federica Bruzzone, Cynthia Dujardin, Jerome Leprince, Helene Tollemer, Youssef Anouar, Mauro Vallarino, Jean Costentin, Hubert Vaudry.
Abstract
In the present study, we report the identification, in the frog brain, of a novel neuropeptide, termed 26RFa, that belongs to the RFamide peptide family. The cDNAs encoding the precursors for 26RFa have been characterized in human and rats. In rats, prepro-26RFa mRNA is expressed exclusively in two hypothalamic nuclei involved in the control of feeding behavior. Intracerebroventricular injection of 26RFa in mice induced a dose-dependent increase in food consumption. Taken together, these data indicate that 26RFa is a novel neuropeptide that may have important biological functions in vertebrates.Entities:
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Year: 2005 PMID： 15891009 DOI： 10.1196/annals.1327.009
Source DB: PubMed Journal: Ann N Y Acad Sci ISSN： 0077-8923 Impact factor: 5.691