Literature DB >> 1589037

[Biosynthesis of peptides: a non-ribosomal system].

H Kleinkauf1, H van Liempt, H Palissa, H von Döhren.   

Abstract

The biosynthesis of peptides in nonribosomal systems is accomplished by complex multienzymes. These multienzymes assemble the required template for the construction of each natural product in the form of linearly coupled modules. This organization principle permits the integration of multistep synthetic processes on a single macromolecule.

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Year:  1992        PMID： 1589037     DOI： 10.1007/bf01134432

Source DB:  PubMed          Journal:  Naturwissenschaften        ISSN： 0028-1042


  32 in total

1.  Cloning and sequencing of a bile acid-inducible operon from Eubacterium sp. strain VPI 12708.

Authors:  D H Mallonee; W B White; P B Hylemon
Journal:  J Bacteriol       Date:  1990-12       Impact factor: 3.490

2.  The cluster of penicillin biosynthetic genes. Identification and characterization of the pcbAB gene encoding the alpha-aminoadipyl-cysteinyl-valine synthetase and linkage to the pcbC and penDE genes.

Authors:  B Díez; S Gutiérrez; J L Barredo; P van Solingen; L H van der Voort; J F Martín
Journal:  J Biol Chem       Date:  1990-09-25       Impact factor: 5.157

Review 3.  Polypeptide synthesis on protein templates: the enzymatic synthesis of gramicidin S and tyrocidine.

Authors:  F Lipmann; W Gevers; H Kleinkauf; R Roskoski
Journal:  Adv Enzymol Relat Areas Mol Biol       Date:  1971

4.  Association of the alpha and beta-2 subunits of the tryptophan synthetase of Escherichia coli.

Authors:  T E Creighton; C Yanofsky
Journal:  J Biol Chem       Date:  1966-02-25       Impact factor: 5.157

5.  The multifunctional 6-methylsalicylic acid synthase gene of Penicillium patulum. Its gene structure relative to that of other polyketide synthases.

Authors:  J Beck; S Ripka; A Siegner; E Schiltz; E Schweizer
Journal:  Eur J Biochem       Date:  1990-09-11

6.  Expression in Escherichia coli of a chemically synthesized gene for the hormone somatostatin.

Authors:  K Itakura; T Hirose; R Crea; A D Riggs; H L Heyneker; F Bolivar; H W Boyer
Journal:  Science       Date:  1977-12-09       Impact factor: 47.728

7.  Cell-free biosynthesis of new cyclosporins.

Authors:  A Lawen; R Traber; D Geyl; R Zocher; H Kleinkauf
Journal:  J Antibiot (Tokyo)       Date:  1989-08       Impact factor: 2.649

8.  Enzymatic synthesis of cyclosporin A.

Authors:  A Billich; R Zocher
Journal:  J Biol Chem       Date:  1987-12-25       Impact factor: 5.157

9.  Analysis of the nucleotide sequence of the Streptomyces glaucescens tcmI genes provides key information about the enzymology of polyketide antibiotic biosynthesis.

Authors:  M J Bibb; S Biró; H Motamedi; J F Collins; C R Hutchinson
Journal:  EMBO J       Date:  1989-09       Impact factor: 11.598

10.  STUDIES ON A BACTERICIDAL AGENT EXTRACTED FROM A SOIL BACILLUS : I. PREPARATION OF THE AGENT. ITS ACTIVITY IN VITRO.

Authors:  R J Dubos
Journal:  J Exp Med       Date:  1939-06-30       Impact factor: 14.307
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  3 in total

Review 1.  Darwin's warm little pond revisited: from molecules to the origin of life.

Authors:  Hartmut Follmann; Carol Brownson
Journal:  Naturwissenschaften       Date:  2009-09-17

Review 2.  The nonribosomal peptide biosynthetic system--on the origins of structural diversity of peptides, cyclopeptides and related compounds.

Authors:  H Kleinkauf; H von Döhren
Journal:  Antonie Van Leeuwenhoek       Date:  1995       Impact factor: 2.271

3.  The peptide synthetase catalyzing cyclosporine production in Tolypocladium niveum is encoded by a giant 45.8-kilobase open reading frame.

Authors:  G Weber; K Schörgendorfer; E Schneider-Scherzer; E Leitner
Journal:  Curr Genet       Date:  1994-08       Impact factor: 3.886
  3 in total

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