Literature DB >> 15889298

A case of Aspergillus mediastinitis after heart transplantation successfully treated with liposomal amphotericin B, caspofungin and voriconazole.

E Forestier1, V Remy, O Lesens, M Martinot, Y Hansman, B Eisenmann, D Christmann.   

Abstract

Reported here is a case of mediastinitis caused by Aspergillus fumigatus and Staphylococcus epidermidis following a heart transplantation that was successfully treated with amphotericin B in combination with new antifungal drugs (caspofungin and voriconazole), antibiotics and superficial wound drainage. A review of the literature revealed that Aspergillus as a cause of mediastinitis has been rarely described. In the few existing reports, evolution was generally fatal, especially in immunocompromised patients, despite treatment with antifungal drugs and surgery.

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Year:  2005        PMID: 15889298     DOI: 10.1007/s10096-005-1327-5

Source DB:  PubMed          Journal:  Eur J Clin Microbiol Infect Dis        ISSN: 0934-9723            Impact factor:   3.267


  17 in total

1.  Sclerosing mediastinitis caused by Aspergillus terreus.

Authors:  S Verghese; T Methew; P Padmaja; A Mullasari; A Sivaraman; V M Kurien
Journal:  Indian J Pathol Microbiol       Date:  2001-04       Impact factor: 0.740

2.  Diagnosis and treatment of Aspergillus flavus sternal wound infections after cardiac surgery.

Authors:  S J Vandecasteele; J R Boelaert; P Verrelst; E Graulus; B Z Gordts
Journal:  Clin Infect Dis       Date:  2002-09-05       Impact factor: 9.079

3.  Mediastinitis in heart transplantation.

Authors:  S V Karwande; D G Renlund; S L Olsen; W A Gay; W E Richenbacher; J A Hawkins; R C Millar; J D Marks
Journal:  Ann Thorac Surg       Date:  1992-12       Impact factor: 4.330

4.  Invasive aspergillosis of the neck and upper mediastinum with intraspinal extension: an unusual presentation.

Authors:  Ghassan S S Atassi; Abdulrahman Al-Shamy
Journal:  Ann Saudi Med       Date:  2002 Jan-Mar       Impact factor: 1.526

5.  Sclerosing mediastinitis and terminal valvular endocarditis caused by fungus suggestive of Aspergillus species.

Authors:  D M Cohen; E A Goggans
Journal:  Am J Clin Pathol       Date:  1971-07       Impact factor: 2.493

6.  Mediastinitis after cardiac transplantation.

Authors:  N A Stolf; A I Fiorelli; F Bacal; L F Camargo; E A Bocchi; A Freitas; A Nicoletti; D Meira
Journal:  Arq Bras Cardiol       Date:  2000-05       Impact factor: 2.000

7.  CDC definitions for nosocomial infections, 1988.

Authors:  J S Garner; W R Jarvis; T G Emori; T C Horan; J M Hughes
Journal:  Am J Infect Control       Date:  1988-06       Impact factor: 2.918

8.  Infectious complications in heart transplant recipients receiving cyclosporine and corticosteroids.

Authors:  J M Hofflin; I Potasman; J C Baldwin; P E Oyer; E B Stinson; J S Remington
Journal:  Ann Intern Med       Date:  1987-02       Impact factor: 25.391

9.  Refractory Aspergillus pneumonia in patients with acute leukemia: successful therapy with combination caspofungin and liposomal amphotericin.

Authors:  Timothy B Aliff; Peter G Maslak; Joseph G Jurcic; Mark L Heaney; Kathleen N Cathcart; Kent A Sepkowitz; Mark A Weiss
Journal:  Cancer       Date:  2003-02-15       Impact factor: 6.860

10.  Outbreak of invasive Aspergillus infection in surgical patients, associated with a contaminated air-handling system.

Authors:  Brock D Lutz; Jiankang Jin; Michael G Rinaldi; Brian L Wickes; Mark M Huycke
Journal:  Clin Infect Dis       Date:  2003-08-28       Impact factor: 9.079

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  5 in total

1.  Concentration-dependent synergy and antagonism within a triple antifungal drug combination against Aspergillus species: analysis by a new response surface model.

Authors:  Joseph Meletiadis; Theodouli Stergiopoulou; Elizabeth M O'Shaughnessy; Joanne Peter; Thomas J Walsh
Journal:  Antimicrob Agents Chemother       Date:  2007-03-26       Impact factor: 5.191

2.  Aspergillus Mediastinitis after Orthotopic Heart Transplantation: A Case Report.

Authors:  Magdy M El-Sayed Ahmed; Abdelkader Almanfi; Muhammad Aftab; Steve K Singh; Hari R Mallidi; O H Frazier
Journal:  Tex Heart Inst J       Date:  2015-10-01

3.  Post-operative Aspergillus mediastinitis in a man who was immunocompetent: a case report.

Authors:  George Dimopoulos; Iraklis Tsangaris; Garyphalia Poulakou; John Panayiotides; George Tsaknis; Stylianos Orfanos; Apostolos Armaganides
Journal:  J Med Case Rep       Date:  2010-09-23

Review 4.  A Rare Case of Aspergillus Mediastinitis After Coronary Artery Bypass Surgery: A Case Report and Literature Review.

Authors:  Otávio Moreli Carneiro Monteiro; Minoru German Higa Júnior; Murillo Augusto Palhares; Maína de Oliveira Nunes; Marcia de Souza Carvalho Melhem; Marilene Rodrigues Chang
Journal:  Am J Case Rep       Date:  2021-12-15

5.  Caspofungin for post solid organ transplant invasive fungal disease: results of a retrospective observational study.

Authors:  M Winkler; J Pratschke; U Schulz; S Zheng; M Zhang; W Li; M Lu; D Sgarabotto; G Sganga; P Kaskel; S Chandwani; L Ma; J Petrovic; M Shivaprakash
Journal:  Transpl Infect Dis       Date:  2010-01-11       Impact factor: 2.228

  5 in total

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