Literature DB >> 15889239

TRPC3: a versatile transducer molecule that serves integration and diversification of cellular signals.

Klaus Groschner1, Christian Rosker.   

Abstract

Transient receptor potential (TRP) proteins have been recognized as sensors for a wide variety of external and internal signals involved in maintenance of cellular homeostasis and control of physiological functions. Evidence of a striking versatility in terms of signal integration and transduction has been reported for members of the canonical (or classical) TRP subfamily (TRPCs). TRPC species are cation channel subunits and emerge as multifunctional signal transduction molecules that are able to function as components of divergent signalplexes. Results obtained in heterologous expression systems suggest TRPC3 as a paradigm of multifunctional signal transduction by a cation channel protein. TRPC3 serves cellular Ca(2+) signaling by multiple mechanisms and may control a variety of distinct physiological functions. In this review, we summarize current knowledge on the properties and possible signaling partners of TRPC3, and discuss the role of TRPC3 channel proteins in cellular signaling networks.

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Year:  2005        PMID： 15889239     DOI： 10.1007/s00210-005-1054-6

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  48 in total

1.  Trp1, a candidate protein for the store-operated Ca(2+) influx mechanism in salivary gland cells.

Authors:  X Liu; W Wang; B B Singh; T Lockwich; J Jadlowiec; B O'Connell; R Wellner; M X Zhu; I S Ambudkar
Journal:  J Biol Chem       Date:  2000-02-04       Impact factor: 5.157

2.  Trp proteins form store-operated cation channels in human vascular endothelial cells.

Authors:  K Groschner; S Hingel; B Lintschinger; M Balzer; C Romanin; X Zhu; W Schreibmayer
Journal:  FEBS Lett       Date:  1998-10-16       Impact factor: 4.124

Review 3.  On the molecular basis and regulation of cellular capacitative calcium entry: roles for Trp proteins.

Authors:  L Birnbaumer; X Zhu; M Jiang; G Boulay; M Peyton; B Vannier; D Brown; D Platano; H Sadeghi; E Stefani; M Birnbaumer
Journal:  Proc Natl Acad Sci U S A       Date:  1996-12-24       Impact factor: 11.205

4.  Properties of heterologously expressed hTRP3 channels in bovine pulmonary artery endothelial cells.

Authors:  M Kamouchi; S Philipp; V Flockerzi; U Wissenbach; A Mamin; L Raeymaekers; J Eggermont; G Droogmans; B Nilius
Journal:  J Physiol       Date:  1999-07-15       Impact factor: 5.182

5.  Stabilization of cortical actin induces internalization of transient receptor potential 3 (Trp3)-associated caveolar Ca2+ signaling complex and loss of Ca2+ influx without disruption of Trp3-inositol trisphosphate receptor association.

Authors:  T Lockwich; B B Singh; X Liu; I S Ambudkar
Journal:  J Biol Chem       Date:  2001-08-27       Impact factor: 5.157

6.  Receptor-activated Ca2+ influx via human Trp3 stably expressed in human embryonic kidney (HEK)293 cells. Evidence for a non-capacitative Ca2+ entry.

Authors:  X Zhu; M Jiang; L Birnbaumer
Journal:  J Biol Chem       Date:  1998-01-02       Impact factor: 5.157

Review 7.  The TRP ion channel family.

Authors:  D E Clapham; L W Runnels; C Strübing
Journal:  Nat Rev Neurosci       Date:  2001-06       Impact factor: 34.870

8.  Assembly of Trp1 in a signaling complex associated with caveolin-scaffolding lipid raft domains.

Authors:  T P Lockwich; X Liu; B B Singh; J Jadlowiec; S Weiland; I S Ambudkar
Journal:  J Biol Chem       Date:  2000-04-21       Impact factor: 5.157

9.  trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry.

Authors:  X Zhu; M Jiang; M Peyton; G Boulay; R Hurst; E Stefani; L Birnbaumer
Journal:  Cell       Date:  1996-05-31       Impact factor: 41.582

10.  Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension.

Authors:  Ying Yu; Ivana Fantozzi; Carmelle V Remillard; Judd W Landsberg; Naomi Kunichika; Oleksandr Platoshyn; Donna D Tigno; Patricia A Thistlethwaite; Lewis J Rubin; Jason X-J Yuan
Journal:  Proc Natl Acad Sci U S A       Date:  2004-09-09       Impact factor: 11.205
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  9 in total

1.  Polymodal TRPC signaling: Emerging role in phenotype switching and tissue remodeling.

Authors:  Klaus Groschner
Journal:  Commun Integr Biol       Date:  2010-09

2.  TRP channels as new pharmacological targets.

Authors:  Thomas Gudermann; Veit Flockerzi
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2005-04       Impact factor: 3.000

Review 3.  The TRPC2 ion channel and pheromone sensing in the accessory olfactory system.

Authors:  F Zufall
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2005-04       Impact factor: 3.000

Review 4.  Structure-function analysis of TRPV channels.

Authors:  Barbara A Niemeyer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2005-04       Impact factor: 3.000

5.  Transient receptor potential (TRP) channels as drug targets.

Authors:  Martin C Michel
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2006-07       Impact factor: 3.000

6.  TRPC3 regulates agonist-stimulated Ca2+ mobilization by mediating the interaction between type I inositol 1,4,5-trisphosphate receptor, RACK1, and Orai1.

Authors:  Geoffrey E Woodard; José J López; Isaac Jardín; Ginés M Salido; Juan A Rosado
Journal:  J Biol Chem       Date:  2009-12-18       Impact factor: 5.157

Review 7.  Functional characterization and physiological relevance of the TRPC3/6/7 subfamily of cation channels.

Authors:  Alexander Dietrich; Michael Mederos y Schnitzler; Hermann Kalwa; Ursula Storch; Thomas Gudermann
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2005-04       Impact factor: 3.000

Review 8.  Regulation of TRPM2 channels in neutrophil granulocytes by ADP-ribose: a promising pharmacological target.

Authors:  Inka Heiner; Natalia Radukina; Jörg Eisfeld; Frank Kühn; Andreas Lückhoff
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2005-04       Impact factor: 3.000

9.  Complex regulation of the TRPC3, 6 and 7 channel subfamily by diacylglycerol and phosphatidylinositol-4,5-bisphosphate.

Authors:  Loïc Lemonnier; Mohamed Trebak; James W Putney
Journal:  Cell Calcium       Date:  2007-10-17       Impact factor: 6.817
  9 in total

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