Literature DB >> 15888916

Interaction between HSP73 and HLA-DRB1*0401: implications for the development of rheumatoid arthritis.

Isabelle Auger1, Jean Roudier.   

Abstract

The amino acid motif QKRAA on HLA-DRB1*0401 carries susceptibility to develop rheumatoid arthritis through unknown mechanisms. We identified the original functions of this motif. In B-cells, HSP73, the constitutive 70-kDa heat-shock protein (HSP), associates with HLA-DRB1*0401. This interaction causes abnormal trafficking of HLA-DRB1*0401. Indeed, HSP73 targets HLA-DRB1*0401 from endoplasmic reticulum to lysosomes bypassing the normal route through the Golgi apparatus and endosomes. In this article, we propose mechanisms to explain how 70-kDa HSPs might contribute to rheumatoid arthritis.

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Year:  2005        PMID： 15888916     DOI： 10.1385/IR:31:3:261

Source DB:  PubMed          Journal:  Immunol Res        ISSN： 0257-277X            Impact factor:   2.829


  22 in total

1.  A function for the QKRAA amino acid motif: mediating binding of DnaJ to DnaK. Implications for the association of rheumatoid arthritis with HLA-DR4.

Authors:  I Auger; J Roudier
Journal:  J Clin Invest       Date:  1997-04-15       Impact factor: 14.808

2.  Specificity of an HLA-DRB1*0401-restricted T cell response to type II collagen.

Authors:  L Fugger; J B Rothbard; G Sonderstrup-McDevitt
Journal:  Eur J Immunol       Date:  1996-04       Impact factor: 5.532

3.  Tolerance to a self-peptide from the third hypervariable region of HLA DRB1*0401 in rheumatoid arthritis patients and normal subjects.

Authors:  S Salvat; I Auger; L Rochelle; A Begovich; L Geburher; A Sette; J Roudier
Journal:  J Immunol       Date:  1994-12-01       Impact factor: 5.422

4.  Cutting edge: receptor-mediated endocytosis of heat shock proteins by professional antigen-presenting cells.

Authors:  D Arnold-Schild; D Hanau; D Spehner; C Schmid; H G Rammensee; H de la Salle; H Schild
Journal:  J Immunol       Date:  1999-04-01       Impact factor: 5.422

5.  The susceptibility sequence to rheumatoid arthritis is a cross-reactive B cell epitope shared by the Escherichia coli heat shock protein dnaJ and the histocompatibility leukocyte antigen DRB10401 molecule.

Authors:  S Albani; J E Tuckwell; L Esparza; D A Carson; J Roudier
Journal:  J Clin Invest       Date:  1992-01       Impact factor: 14.808

6.  Aberrant extracellular and dendritic cell (DC) surface expression of heat shock protein (hsp)70 in the rheumatoid joint: possible mechanisms of hsp/DC-mediated cross-priming.

Authors:  Carla A Martin; Steven E Carsons; Robert Kowalewski; David Bernstein; Michael Valentino; Frances Santiago-Schwarz
Journal:  J Immunol       Date:  2003-12-01       Impact factor: 5.422

7.  Major differences in antigen-processing correlate with a single Arg71<-->Lys substitution in HLA-DR molecules predisposing to rheumatoid arthritis and with their selective interactions with 70-kDa heat shock protein chaperones.

Authors:  Sabine Roth; Nicholas Willcox; Rita Rzepka; Matthias P Mayer; Inga Melchers
Journal:  J Immunol       Date:  2002-09-15       Impact factor: 5.422

8.  Hsp70 promotes antigen-presenting cell function and converts T-cell tolerance to autoimmunity in vivo.

Authors:  Douglas G Millar; Kristine M Garza; Bernhard Odermatt; Alisha R Elford; Nobuyuki Ono; Zihai Li; Pamela S Ohashi
Journal:  Nat Med       Date:  2003-11-16       Impact factor: 53.440

9.  HLA-DR4 and HLA-DR10 motifs that carry susceptibility to rheumatoid arthritis bind 70-kD heat shock proteins.

Authors:  I Auger; J M Escola; J P Gorvel; J Roudier
Journal:  Nat Med       Date:  1996-03       Impact factor: 53.440

10.  Receptor-mediated uptake of antigen/heat shock protein complexes results in major histocompatibility complex class I antigen presentation via two distinct processing pathways.

Authors:  F Castellino; P E Boucher; K Eichelberg; M Mayhew; J E Rothman; A N Houghton; R N Germain
Journal:  J Exp Med       Date:  2000-06-05       Impact factor: 14.307
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  5 in total

1.  HLA-DRB1*0404 is strongly associated with anticalpastatin antibodies in rheumatoid arthritis.

Authors:  Isabelle Auger; Chantal Roudier; Sandrine Guis; Nathalie Balandraud; Jean Roudier
Journal:  Ann Rheum Dis       Date:  2007-02-26       Impact factor: 19.103

Review 2.  Possible roles of anti-type II collagen antibody and innate immunity in the development and progression of diabetic retinopathy.

Authors:  Tsunehiko Ikeda; Kimitoshi Nakamura; Teruyo Kida; Hidehiro Oku
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2021-08-11       Impact factor: 3.535

Review 3.  A central role for inducible heat-shock protein 70 in autoimmune vitiligo.

Authors:  Jeffrey A Mosenson; Jonathan M Eby; Claudia Hernandez; I Caroline Le Poole
Journal:  Exp Dermatol       Date:  2013-06-20       Impact factor: 3.960

Review 4.  How Rheumatoid Arthritis Can Result from Provocation of the Immune System by Microorganisms and Viruses.

Authors:  Marina I Arleevskaya; Olga A Kravtsova; Julie Lemerle; Yves Renaudineau; Anatoly P Tsibulkin
Journal:  Front Microbiol       Date:  2016-08-17       Impact factor: 5.640

Review 5.  Rheumatoid Arthritis, Immunosenescence and the Hallmarks of Aging.

Authors:  Paulina Chalan; Anke van den Berg; Bart-Jan Kroesen; Liesbeth Brouwer; Annemieke Boots
Journal:  Curr Aging Sci       Date:  2015
  5 in total

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