| Literature DB >> 15888457 |
Yoshifumi Imamura1, Katsunori Yanagihara1, Kazunori Tomono1, Hideaki Ohno1, Yasuhito Higashiyama1, Yoshitsugu Miyazaki1, Yoichi Hirakata1, Yohei Mizuta1, Jun-Ichi Kadota1, Kazuhiro Tsukamoto1, Shigeru Kohno1.
Abstract
The role of quorum-sensing systems in a mouse model of chronic Pseudomonas aeruginosa infection was studied. A chronic P. aeruginosa respiratory infection model was established by placement of a tube pre-coated with strain PAO1 (wild-type) or a quorum-sensing mutant, namely PAO-JP1 (Delta lasI), PDO100 (Delta rhlI) or PAO-JP2 (Delta lasI/Delta rhlI), in the bronchus. At day 14 after infection, the numbers of viable bacteria in the quorum-sensing-mutant groups were lower than in the wild-type group. Histopathological examination showed milder inflammatory changes in the lungs infected with the mutant groups compared with the wild-type group. In the bronchoalveolar lavage fluid from the quorum-sensing-system-mutant groups the proportion of neutrophils was lower than in wild-type group. These findings indicate that the quorum-sensing system plays an important role in chronic P. aeruginosa respiratory infection.Entities:
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Year: 2005 PMID： 15888457 DOI： 10.1099/jmm.0.46004-0
Source DB: PubMed Journal: J Med Microbiol ISSN： 0022-2615 Impact factor: 2.472