Literature DB >> 15888310

Mechanism and applications of phosphite dehydrogenase.

Heather A Relyea1, Wilfred A van der Donk.   

Abstract

Phosphite dehydrogenase catalyzes the NAD+-dependent oxidation of hydrogen phosphonate (common name phosphite) to phosphate in what amounts to a formal phosphoryl transfer reaction from hydride to hydroxide. This review places the enzyme in the context of phosphorus redox metabolism in nature and discusses the results of mechanistic investigations into its reaction mechanism. The potential of the enzyme as a NAD(P)H cofactor regeneration system is discussed as well as efforts to engineer the cofactor specificity of the protein.

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Year:  2005        PMID： 15888310     DOI： 10.1016/j.bioorg.2005.01.003

Source DB:  PubMed          Journal:  Bioorg Chem        ISSN： 0045-2068            Impact factor:   5.275


  14 in total

Review 1.  Rings, radicals, and regeneration: the early years of a bioorganic laboratory.

Authors:  Wilfred A van der Donk
Journal:  J Org Chem       Date:  2006-12-22       Impact factor: 4.354

2.  Metagenomics-guided analysis of microbial chemolithoautotrophic phosphite oxidation yields evidence of a seventh natural CO2 fixation pathway.

Authors:  Israel A Figueroa; Tyler P Barnum; Pranav Y Somasekhar; Charlotte I Carlström; Anna L Engelbrektson; John D Coates
Journal:  Proc Natl Acad Sci U S A       Date:  2017-11-28       Impact factor: 11.205

Review 3.  Redox cofactor engineering in industrial microorganisms: strategies, recent applications and future directions.

Authors:  Jiaheng Liu; Huiling Li; Guangrong Zhao; Qinggele Caiyin; Jianjun Qiao
Journal:  J Ind Microbiol Biotechnol       Date:  2018-03-27       Impact factor: 3.346

4.  Examining the Mechanism of Phosphite Dehydrogenase with Quantum Mechanical/Molecular Mechanical Free Energy Simulations.

Authors:  David R Stevens; Sharon Hammes-Schiffer
Journal:  Biochemistry       Date:  2020-02-14       Impact factor: 3.162

5.  Pre-steady-state studies of phosphite dehydrogenase demonstrate that hydride transfer is fully rate limiting.

Authors:  Emily J Fogle; Wilfred A van der Donk
Journal:  Biochemistry       Date:  2007-10-20       Impact factor: 3.162

6.  Crystal structures of phosphite dehydrogenase provide insights into nicotinamide cofactor regeneration.

Authors:  Yaozhong Zou; Houjin Zhang; Joseph S Brunzelle; Tyler W Johannes; Ryan Woodyer; John E Hung; Nikhil Nair; Wilfred A van der Donk; Huimin Zhao; Satish K Nair
Journal:  Biochemistry       Date:  2012-05-17       Impact factor: 3.162

7.  Temperature-Independent Kinetic Isotope Effects as Evidence for a Marcus-like Model of Hydride Tunneling in Phosphite Dehydrogenase.

Authors:  Graeme W Howe; Wilfred A van der Donk
Journal:  Biochemistry       Date:  2019-10-07       Impact factor: 3.162

8.  Nonsterile l-Lysine Fermentation Using Engineered Phosphite-Grown Corynebacterium glutamicum.

Authors:  Ming Lei; Xiwei Peng; Wenjun Sun; Di Zhang; Zhenyu Wang; Zhengjiao Yang; Chong Zhang; Bin Yu; Huanqing Niu; Hanjie Ying; Pingkai Ouyang; Dong Liu; Yong Chen
Journal:  ACS Omega       Date:  2021-04-07

9.  The molecular basis of phosphite and hypophosphite recognition by ABC-transporters.

Authors:  Claudine Bisson; Nathan B P Adams; Ben Stevenson; Amanda A Brindley; Despo Polyviou; Thomas S Bibby; Patrick J Baker; C Neil Hunter; Andrew Hitchcock
Journal:  Nat Commun       Date:  2017-11-23       Impact factor: 14.919

10.  Investigation of the role of Arg301 identified in the X-ray structure of phosphite dehydrogenase.

Authors:  John E Hung; Emily J Fogle; Harry D Christman; Tyler W Johannes; Huimin Zhao; William W Metcalf; Wilfred A van der Donk
Journal:  Biochemistry       Date:  2012-05-17       Impact factor: 3.162
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