Literature DB >> 15888307

Oxidative cascades: a facile biosynthetic strategy for the assembly of complex molecules.

Pieter Dorrestein1, Tadhg P Begley.   

Abstract

Electron-rich aromatic compounds undergo a facile tandem reaction sequence involving an iterative two-electron oxidation/aromatization. This review will describe the application of this motif to the synthesis of dimethylbenzimidazole, pyoverdine, actinomycin, cystodytin, pyrroloquinoline quinone, and the cataract pigment.

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Year:  2005        PMID： 15888307     DOI： 10.1016/j.bioorg.2004.06.006

Source DB:  PubMed          Journal:  Bioorg Chem        ISSN： 0045-2068            Impact factor:   5.275


  3 in total

Review 1.  Nonribosomal peptide synthetase biosynthetic clusters of ESKAPE pathogens.

Authors:  Andrew M Gulick
Journal:  Nat Prod Rep       Date:  2017-08-02       Impact factor: 13.423

2.  Three-dimensional structures of Pseudomonas aeruginosa PvcA and PvcB, two proteins involved in the synthesis of 2-isocyano-6,7-dihydroxycoumarin.

Authors:  Eric J Drake; Andrew M Gulick
Journal:  J Mol Biol       Date:  2008-09-19       Impact factor: 5.469

3.  A Remarkable Oxidative Cascade That Replaces the Riboflavin C8 Methyl with an Amino Group during Roseoflavin Biosynthesis.

Authors:  Isita Jhulki; Prem K Chanani; Sameh H Abdelwahed; Tadhg P Begley
Journal:  J Am Chem Soc       Date:  2016-06-29       Impact factor: 15.419
  3 in total

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