OBJECTIVE: An association between high-risk human papillomavirus (HR HPV) infection and a risk of development of a subgroup of head and neck cancers has been proposed recently. The main risk factors of oral and oropharyngal cancer observed in our population are smoking and alcohol consumption. The incidence of oral/oropharyngeal tumours in the Czech Republic is relatively high and there are no data available about the prevalence of HPV DNA presence in these tumours. MATERIALS AND METHODS: Eighty patients with a primary oropharyngeal cancer were enrolled. The presence of HPV DNA has been evaluated by polymerase chain reaction in 68 cases from which the tumour tissue and demographical and clinical data were available. The typing of HPV was performed by nucleotide DNA sequencing. RESULTS: The HPV DNA was detected in 51.5% of samples tested. Among the HPV DNA positive tumours, 80% contained HPV16. In the analysed group there were 54 men and 14 women. The prevalence of HPV DNA was lower in oral (25%) than in oropharyngeal (57%) tumours, and higher in never smokers (100%) and never drinkers (68.8%). HPV DNA presence was not related to gender, age, number of lifetime sexual partners or practice of oral-genital sex, size of tumour or presence of regional metastases. CONCLUSIONS: The difference in the prevalence of HPV DNA positive tumours between cases of oral cavity and oropharyngeal carcinoma exposed and not exposed to tobacco or alcohol support the theory that HPV DNA positive tumours form an aetiologically distinct subgroup of head and neck tumours.
OBJECTIVE: An association between high-risk human papillomavirus (HR HPV) infection and a risk of development of a subgroup of head and neck cancers has been proposed recently. The main risk factors of oral and oropharyngal cancer observed in our population are smoking and alcohol consumption. The incidence of oral/oropharyngeal tumours in the Czech Republic is relatively high and there are no data available about the prevalence of HPV DNA presence in these tumours. MATERIALS AND METHODS: Eighty patients with a primary oropharyngeal cancer were enrolled. The presence of HPV DNA has been evaluated by polymerase chain reaction in 68 cases from which the tumour tissue and demographical and clinical data were available. The typing of HPV was performed by nucleotide DNA sequencing. RESULTS: The HPV DNA was detected in 51.5% of samples tested. Among the HPV DNA positive tumours, 80% contained HPV16. In the analysed group there were 54 men and 14 women. The prevalence of HPV DNA was lower in oral (25%) than in oropharyngeal (57%) tumours, and higher in never smokers (100%) and never drinkers (68.8%). HPV DNA presence was not related to gender, age, number of lifetime sexual partners or practice of oral-genital sex, size of tumour or presence of regional metastases. CONCLUSIONS: The difference in the prevalence of HPV DNA positive tumours between cases of oral cavity and oropharyngeal carcinoma exposed and not exposed to tobacco or alcohol support the theory that HPV DNA positive tumours form an aetiologically distinct subgroup of head and neck tumours.
Authors: Jay H Lubin; Joshua Muscat; Mia M Gaudet; Andrew F Olshan; Maria Paula Curado; Luigino Dal Maso; Victor Wünsch-Filho; Erich M Sturgis; Neonilia Szeszenia-Dabrowska; Xavier Castellsague; Zuo-Feng Zhang; Elaine Smith; Leticia Fernandez; Elena Matos; Silvia Franceschi; Eleonora Fabianova; Peter Rudnai; Mark P Purdue; Dana Mates; Qingyi Wei; Rolando Herrero; Karl Kelsey; Hal Morgenstern; Oxana Shangina; Sergio Koifman; Jolanta Lissowska; Fabio Levi; Alexander W Daudt; Jose Eluf Neto; Chu Chen; Philip Lazarus; Deborah M Winn; Stephen M Schwartz; Paolo Boffetta; Paul Brennan; Ana Menezes; Carlo La Vecchia; Michael McClean; Renato Talamini; Thangarajan Rajkumar; Richard B Hayes; Mia Hashibe Journal: Cancer Causes Control Date: 2011-07-09 Impact factor: 2.506
Authors: L Mannarini; V Kratochvil; L Calabrese; L Gomes Silva; P Morbini; J Betka; M Benazzo Journal: Acta Otorhinolaryngol Ital Date: 2009-06 Impact factor: 2.124
Authors: Jan Laco; Hana Vosmikova; Vendula Novakova; Petr Celakovsky; Helena Dolezalova; Lubos Tucek; Jana Nekvindova; Milan Vosmik; Eva Cermakova; Ales Ryska Journal: Virchows Arch Date: 2011-01-11 Impact factor: 4.064
Authors: Jan Klozar; Vit Kratochvil; Martina Salakova; Jana Smahelova; Eva Vesela; Eva Hamsikova; Jan Betka; Ruth Tachezy Journal: Eur Arch Otorhinolaryngol Date: 2007-12-20 Impact factor: 2.503