Literature DB >> 15887243

ETV6 gene rearrangements in invasive breast carcinoma.

Anne Letessier1, Christophe Ginestier, Emmanuelle Charafe-Jauffret, Nathalie Cervera, José Adélaïde, Véronique Gelsi-Boyer, Jean-Charles Ahomadegbe, Jean Benard, Jocelyne Jacquemier, Daniel Birnbaum, Max Chaffanet.   

Abstract

The ETV6/TEL gene encodes a transcription factor frequently rearranged in several types of cancer. We looked for ETV6 rearrangements in invasive breast cancer using fluorescence in situ hybridization (FISH) of BAC probes on sections of tissue microarrays containing 632 tumor samples. Of these samples, signal of sufficient quality for screening by FISH was obtained for 356. Five cases (one lobular, one nontypical secretory, one mixed, and two ductal carcinomas) showed ETV6 rearrangement. (c) 2005 Wiley-Liss, Inc.

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Year:  2005        PMID： 15887243     DOI： 10.1002/gcc.20200

Source DB:  PubMed          Journal:  Genes Chromosomes Cancer        ISSN： 1045-2257            Impact factor:   5.006


  9 in total

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