Literature DB >> 15885884

Expression of candidate chromosome 3p21.3 tumor suppressor genes and down-regulation of BLU in some esophageal squamous cell carcinomas.

Paulisally Hau Yi Lo1, Alfred Chi Chung Leung, Wenjun Xiong, Simon Law, Fuh-Mei Duh, Michael I Lerman, Eric J Stanbridge, Maria Li Lung.   

Abstract

The expression of six chromosome 3p21.3 candidate tumor suppressor genes (BLU, FUS2, HYAL2, NPRL2, RASSF1A, and SEMA3B) in esophageal squamous cell carcinoma (ESCC) has been investigated. Reduced expression of BLU was detected in some ESCC cell lines and tumor tissues and the difference was quantitated by real-time quantitative polymerase chain reaction. Methylation specific-PCR revealed the down-regulation of BLU by epigenetic inactivation. However, exogenous expression of BLU did not functionally suppress tumorigenicity in nude mice. These results suggest that over-expression of BLU alone is not sufficient to inhibit tumorigenicity. Further studies on BLU interacting proteins are required to elucidate the possible role of BLU in the development of ESCC.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 15885884     DOI： 10.1016/j.canlet.2005.03.036

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  10 in total

1.  Tumor suppressor gene BLU is frequently downregulated by promoter hypermethylation in myelodysplastic syndrome.

Authors:  Yujuan Yang; Qingxia Zhang; Feng Xu; Lingyun Wu; Qi He; Xiao Li
Journal:  J Cancer Res Clin Oncol       Date:  2012-01-15       Impact factor: 4.553

2.  Decreased expression of NPRL2 in renal cancer cells is associated with unfavourable pathological, proliferation and apoptotic features.

Authors:  Yongyong Tang; Li Jiang; Wei Tang
Journal:  Pathol Oncol Res       Date:  2014-05-01       Impact factor: 3.201

3.  Relationship between tumor and peripheral blood NPRL2 mRNA levels in patients with colorectal adenoma and colorectal cancer.

Authors:  Ai-yun Liu; Dian-Ggang Liu; Ya-ju Du; Feng-hua Pei; Guang Yang; Bing-rong Liu; Hui-tao Zhang; Xin-hong Wang; Yu-jing Fan; Ying-zhun Chen; Yang Jiang; Jing Chen
Journal:  Cancer Biol Ther       Date:  2014-02-12       Impact factor: 4.742

4.  Tumor suppressor TSLC1 inhibits growth, proliferation, invasiveness and angiogenesis in nude mice xenografted tumor of Eca109 cells.

Authors:  Qi-Lian Liang; Guo-Qiang Chen; Qiu-Long Liu; Zhou-Yu Li; Xiang-Ning Zhang; Yuan Zhou; Wen-Ting Ou; Bi-Rong Wang; Li-Ren Hu
Journal:  Int J Clin Exp Med       Date:  2014-06-15

5.  Mandatory chromosomal segment balance in aneuploid tumor cells.

Authors:  Maria Kost-Alimova; Eva Darai-Ramqvist; Wing Lung Yau; Agneta Sandlund; Ludmila Fedorova; Ying Yang; Irina Kholodnyuk; Yue Cheng; Maria Li Lung; Eric Stanbridge; George Klein; Stefan Imreh
Journal:  BMC Cancer       Date:  2007-01-26       Impact factor: 4.430

6.  Anti-angiogenic pathway associations of the 3p21.3 mapped BLU gene in nasopharyngeal carcinoma.

Authors:  Y Cheng; R L K Y Ho; K C Chan; R Kan; E Tung; H L Lung; W L Yau; A K L Cheung; J M Y Ko; Z F Zhang; D Z Luo; Z B Feng; S Chen; X Y Guan; D Kwong; E J Stanbridge; M L Lung
Journal:  Oncogene       Date:  2014-10-27       Impact factor: 9.867

7.  Tumor suppressor BLU promotes TRAIL-induced apoptosis by downregulating NF-κB signaling in nasopharyngeal carcinoma.

Authors:  Jiahui Zhou; Zunnan Huang; Ziyou Wang; Shumin Liu; Alf Grandien; Ingemar Ernberg; Zhiwei He; Xiangning Zhang
Journal:  Oncotarget       Date:  2017-07-04

8.  ZMYND10, an epigenetically regulated tumor suppressor, exerts tumor-suppressive functions via miR145-5p/NEDD9 axis in breast cancer.

Authors:  Yan Wang; Liangying Dan; Qianqian Li; Lili Li; Lan Zhong; Bianfei Shao; Fang Yu; Sanxiu He; Shaorong Tian; Jin He; Qian Xiao; Thomas C Putti; Xiaoqian He; Yixiao Feng; Yong Lin; Tingxiu Xiang
Journal:  Clin Epigenetics       Date:  2019-12-04       Impact factor: 6.551

9.  Identification of cilia genes that affect cell-cycle progression using whole-genome transcriptome analysis in Chlamydomonas reinhardtti.

Authors:  Alison J Albee; Alan L Kwan; Huawen Lin; David Granas; Gary D Stormo; Susan K Dutcher
Journal:  G3 (Bethesda)       Date:  2013-06-21       Impact factor: 3.154

Review 10.  Promoter methylation of tumor suppressor genes in esophageal squamous cell carcinoma.

Authors:  Ji-Sheng Li; Jian-Ming Ying; Xiu-Wen Wang; Zhao-Hui Wang; Qian Tao; Li-Li Li
Journal:  Chin J Cancer       Date:  2012-05-08
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.